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Old 01-24-2011, 01:15 PM   #1 (permalink)
 
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Default sexual side effects on 50mg zoloft

Have been taking 50mg zoloft for about a week after two month introductory dose of 25mg. I understand that this is the lowest dose for anxiety treatment and its really made a difference. However, I am not able to reach climax or ejaculate during sex... also having trouble when I masturbate. I get tired pretty quickly as well. Are these side effects going to resolve themselves as I adjust to the new dosage or should I be concerned. I'm loath to start taking any additional meds. Any advice?
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Old 01-24-2011, 03:33 PM   #2 (permalink)
 
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Welcome to the not-so-wonderful world of SSRIs.

SSRIs have a VERY high rate of sexual side effects, with anorgasmia (not being able to ejaculate) being the most common. My brother got off SSRIs because of that issue. He described it as "like having a gun that's cocked & loaded, but won't fire" (and this metaphor was his, and he's not even interested in guns at all).

Oddly, my own experience with Zoloft was that I could orgasm even at 300 mg, though had no sex drive at all, thus making the ability to orgasm rather pointless. Paxil & Prozac didn't kill sex drive, though they provided the frustration you're experiencing, of not being able to orgasm. With Paxil I found the effect was clearly dosage-related. At 40 mg it was very difficult. At 60 mg, not a chance of orgasm no matter what.

SSRIs are even prescribed for the treatment of premature ejaculation due to this common side effect they have. Hell, it's hard to even call it a side effect when that's one of the things SSRIs are specifically used for. I wonder how many of the guys in porn use some SSRI (along with their Viagra) to ensure they keep going & going for the stunningly long time required in that line of work.

Drug companies are very much aware of this problem. I can tell you from personal experience that in a clinical trial they'll never ask you about sexual side effects. Being cynical, I'm sure it's because they have a don't ask, don't tell policy. They don't ask as they don't want negative information that would then be required on their official FDA-approved label. And they hope & pray trial participants don't tell them about sexual issues, such that they can officially pretend such problems are rare. They will ask about every other unlikely side effect under the sun, such as "does it give you gas?" Knowing their pills don't cause farting, I guess they feel comfortable asking stupid stuff like that.
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Old 01-24-2011, 03:44 PM   #3 (permalink)
 
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There is a chance that the sexual side effects will fade eventually. I was on fluoxetine for a number of months and after about 3 months or so the sexual side effects faded a bit, but not completely. After about 5 months on that particular Selective Sperm Release Inhibitor I stopped 'cause it wasn't helping my S.A.
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Old 01-24-2011, 04:39 PM   #4 (permalink)
 
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Some things you could ask your doctor about: wellbutrin, dopamine agonists, low dose amphetamine, cyproheptadine, maybe even low dose naltrexone though I dunno if it works all that well.

Some things you could take on your own: maca, yohimbe


Edit: "Selective Sperm Release Inhibitor" This made me lol
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Old 01-24-2011, 05:00 PM   #5 (permalink)
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I don't meant to change the subject, but I wonder if another brand will ever come up with a SSRI that tries to minimize this side effect? Sex sells, in this case literally, so why not? I can imagine it doing the opposite though, too much sex drive. What case would be worse?
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Old 01-24-2011, 08:22 PM   #6 (permalink)
 
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Every time my dose gets upped I have a period for about a month-ish where it's really hard to reach orgasm. :-\ Possible, but takes forever, which isn't always a bad thing.
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Old 01-24-2011, 08:37 PM   #7 (permalink)
 
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Quote:
Originally Posted by yes View Post
I don't meant to change the subject, but I wonder if another brand will ever come up with a SSRI that tries to minimize this side effect? Sex sells, in this case literally, so why not? I can imagine it doing the opposite though, too much sex drive. What case would be worse?
It's here - well, it's approved by the FDA and will be released in Q2 this year. See this topic on Vilazodone:
http://www.socialanxietysupport.com/...zodone-109563/
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Old 01-25-2011, 12:24 AM   #8 (permalink)
 
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I was prescribed sertraline for premature ejaculation and i come quick even at 200mg and i have regular sex (3-5 times a week) for 7 years and my libido is also very high. i'm sooo over "sensitive" i get so excited that i cum in seconds. don't know what to do? anyone in the same boat? any suggestions? sertraline DOES help but not even close to "not able to orgasm"...
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Old 01-25-2011, 12:30 AM   #9 (permalink)
 
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Hahahhahhahahaha!!!!!!!!!!!!!

Ya u have to trade your sexual function for an ssri. Lexapro killed my libido. It took me
an hour of exhaustion an sweat just to reach a ****ty climax. I quit
lexapro recently and my libido is back..... Its not like i use it anyway though.
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Old 02-14-2011, 09:28 PM   #10 (permalink)
 
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Quote:
Originally Posted by ka13 View Post
Have been taking 50mg zoloft for about a week after two month introductory dose of 25mg. I understand that this is the lowest dose for anxiety treatment and its really made a difference. However, I am not able to reach climax or ejaculate during sex... also having trouble when I masturbate. I get tired pretty quickly as well. Are these side effects going to resolve themselves as I adjust to the new dosage or should I be concerned. I'm loath to start taking any additional meds. Any advice?
I took 100mg Zoloft for about a year. Couple things I noticed:

- Every time I changed dosage, whether up or down, I had about 1-2 weeks of severe fatigue. It always went away though. During these periods of fatigue, I found one thing that consistently helped: EXERCISE.

- Before taking Zoloft, I had a very strong sex drive. Also, I would last 5-10 minutes in bed on average. While taking it, my sex drive all but disappeared, and I would last literally 60-90 minutes in bed, if I orgasmed at all. That was consistent the entire time I was on Zoloft. When I finally stopped taking it (I stopped cold turkey - not the best idea btw) it took about 2 weeks for me to get back to normal.

I wouldn't be concerned about the fatigue. My roommate also takes Zoloft and has similar issues with it. I once dated a girl who was also on Zoloft and she had the same issues as well. My psychiatrist told me that it was pretty common. It always goes away.

The delayed ejaculation probably won't go away until you stop taking it though. In fact, Zoloft has an off label use as a treatment for premature ejaculation (Google "sertraline premature ejaculation").

BTW, when my girlfriend and I were both on Zoloft, sex was a little weird. We would go for a few hours until we were both finally like "All right this is ridiculous, let's watch TV instead." But, it was still fun - it helps when you have a partner with a sense of humor. :-)

So, to summarize, for me and the other I've known who have taken it:

- Fatigue on dosage miss/change: Goes away after a few weeks; exercise helps a lot, sunlight, stay active - all good things to do anyways.
- Delayed orgasm: Very common, sticks around until you stop taking it.
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Old 02-14-2011, 09:51 PM   #11 (permalink)
 
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BTW, a couple more things to say about Zoloft:

1. For the fatigue, if you really can't deal with it at all, ask your doctor about Provigil (modafinil). It's normally prescribed to treat narcolepsy and sleep apnea-related fatigue, but I would take it as-needed and it helped me get through some rough Zoloft fatigue some times and did not make me jittery or "stoned". http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000196

2. You know, IMO, drugs like Zoloft are a valuable *tool*. For me, Zoloft would not have solved my problems forever, and I didn't expect it to. In fact, it didn't "solve" my problems at all. But, it really put me in a space where I could concentrate on learning more about myself, and gave me an opportunity to develop great new tools for dealing with my own anxieties and problems. I was only on it for about a year, and when I got off it, even though the same old emotions came back, I was in a great position to deal with them, and really had permanently improved a lot. I really felt I used the opportunities it gave me, and I stopped it when I felt I was ready to go on my own again. I went into it with that attitude and, knowing it was just a temporary tool I think really helped me accept any of the other side effects. Lasting an hour and a half in bed for a year was kind of worth the lifetime of positive changes I ended up making. :-)

Note: I had another post I made before this that's still waiting for moderator approval. This one might make more sense after reading that one, which will probably be posted after this one, lol. Oh well.
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Old 02-14-2011, 10:42 PM   #12 (permalink)
 
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Paxil is the worst for Sex Drive and Ejaculation Problems. The Most reported side effect with Paxil is Ejaculation problems........destroys your libido. And a interesting little thing from Wikipedia on paxil (Paroxetine) Several studies have suggested that paroxetine can be used in the treatment of premature ejaculation. In particular, intravaginal ejaculation latency time (IELT) was found to increase with 6-13-fold, which was somewhat longer than the delay achieved by the treatment with other SSRIs (fluvoxamine, fluoxetine, sertraline, and citalopram So if your having bad luck with using Zoloft as your premature ejaculation med try Paxil it cant fail. Literally everyone on paxil has sexual side effects, If you don't get sexual side effects Go buy lottery tickets, your lucky. Zoloft has partial effects on dopamine. Paxil is all Serotonin and very selective at 5HT Sites.
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Old 06-11-2013, 03:25 PM   #13 (permalink)
 
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I have been on zoloft since Decemeber and eventhough it helped me desire my husband more, I found I couldn't get aroused or ever reach orgasm. After about 6 months of frustration I finally found a website that offered herbal remedies. I had heard about taking Wellbutrin to offset what zoloft was effecting sexually, but I do not like to take Rx medicines if I can help it so I wanted a more natural alternative. I found this website site http://www.tinamariebernard.com/2012...womans-libido/ and I tried the first supplement mentioned, the arginine. I purchased it from Amazon because I was willing to give it a try. It's been three weeks and I've been taking it once a day and I am able to get aroused and I've reached orgasm twice! This is exactly what I ordered. http://www.amazon.com/Super-Strength...rds=l+arginine I feel so good about taking something natural that's good for me to begin with let alone something that helps my relationship with my husband! There is hope! I felt very torn....depression vs sex life. I don't believe we have to chose! This also helps with natural secretions as they were gone as well. I was always having to use a lubricant. I hope this helps you like it's helped me!
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Old 06-11-2013, 03:33 PM   #14 (permalink)
 
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SSRIs do suck with their awful sexual side effects. It sucks having anxiety but having to choose between that or sex drive. They really need to come up with a good anti-depressant/anti-anxiety med that is NOT an ssri and not a benzo that will improve anxiety but not create other problems like sexual issues. I'm in my 30s and paxil has worked great for me for anxiety but the sexual side effects really suck. I don't really think about sex often anymore anyways, but even if I did, I doubt I could do much about it. I wonder if ssris affect females as badly in that respect as they seem to males.

I hope the drug companies come up with some better options in the future.
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Old 11-28-2013, 07:53 AM   #15 (permalink)
 
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it does affect females too...no orgasm on ssris for me. im now on trimipramine, which does alot against my anxiety, but it makes me drowsy after the tiredness of the first weeks, i didnt really notice. but now i have to study for exams, and i just cant remember anything. this is terrible, bc ssris are no option for me anymore. im now trying to reduce the dosage of trimipramine (50mg now) and then see if i can handle my emotions. i already got alot better, even tho i had a dosage reduction. so staying positive...

still: does anyone have experience with imipramine and sexual side effects/ concentration issues?
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Old 12-24-2013, 02:20 PM   #16 (permalink)
 
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Cool Similar situation

Quote:
Originally Posted by Barbapapa View Post
I was prescribed sertraline for premature ejaculation and i come quick even at 200mg and i have regular sex (3-5 times a week) for 7 years and my libido is also very high. i'm sooo over "sensitive" i get so excited that i cum in seconds. don't know what to do? anyone in the same boat? any suggestions? sertraline DOES help but not even close to "not able to orgasm"...
I understand your frustration, suffered with it for many years! I also used to be a quick shot...been on 50mg zoloft for about 2 years, on 100mg for the last year or so. Cured my problem, last a long time now, sex drive is good too. I am also a regular cannabis user and I'm sure that helps a lot as well. I know it's not an option for everyone, but from my experience, (and others I know), it does help.
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Old 12-24-2013, 02:33 PM   #17 (permalink)
 
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Yea same happened to me. It sucked because the girls I was with were freaks like 3 times a day freaks. But I was able to finish sometimes. Had to turn down sex a lot which they took personal
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Old 12-27-2013, 01:03 PM   #18 (permalink)
 
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Quote:
Originally Posted by AlexP7 View Post
I wonder if ssris affect females as badly in that respect as they seem to males.

I hope the drug companies come up with some better options in the future.
Yes it does. I had a female friend on celexa.

No lubrication (painful sex). No orgasms. And eventually no sex drive.
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Old 12-27-2013, 05:44 PM   #19 (permalink)
 
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Yeah I have gotten that since I started taking SSRI's 5 years ago.

Unfortunately its a catch 22 really. Its nearly like it takes those good feelings away and gives them to you over the course of your day lol
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