SAS Wikipedia Pharmacology Project

[jim_morrison]

Thought I'd contribute by posting a link to an interesting article which I recently came across regarding Mirtazapine and Venlafaxines possible antinociceptive effects at the opoid receptors, contributing to their supposed superiority in treating severe and treatment resistant depression (and possibly SA).

here's the article:
http://www.springerlink.com/content/2kx87825w7017h47/
http://opioids.com/depression/antidepressants.html


And also a user report for good measure:
http://www.depressionforums.org/foru...in-t35176.html

[rocknroll714]

Originally Posted by jim_morrison

Agreed! I'm reading the Hedonistic Imperative at the moment, interesting stuff.

Btw heres an article on mirtazapine i think you might be interested in if you havn't already came across it.
http://www.pslgroup.com/dg/2030e2.htm

Thank you, I'll take a look at it sometime.

Originally Posted by jim_morrison

Thought I'd contribute by posting a link to an interesting article which I recently came across regarding Mirtazapine and Venlafaxines possible antinociceptive effects at the opoid receptors, contributing to their supposed superiority in treating severe and treatment resistant depression (and possibly SA).

here's the article:
http://www.springerlink.com/content/2kx87825w7017h47/
http://opioids.com/depression/antidepressants.html


And also a user report for good measure:
http://www.depressionforums.org/foru...in-t35176.html

I'll take a look at those as well.

[rocknroll714]

I've been kinda lazy / out of it on account of my phenelzine (Nardil) causing apathy.. haven't done a whole lot of work on Wikipedia at all. Hopefully my phenelzine starts kicking in all the way sometime soon, or maybe combining mirtazapine (Remeron) will fix me up.. who knows.

This is why we need YOUR help! :D

[LostPancake]

I was looking up paxil, because I wanted to know if caffeine affected the metabolism of it, but instead wound up adding an article on a relatively newly discovered (2004) monoamine transporter, PMAT.

http://en.wikipedia.org/wiki/Plasma_...ne_transporter

The SSRI's apparently don't affect it much. Another drug target!

I still want to know about the caffeine though - I'll have to pursue it later.

One thing though, for SERT they have a tag at the top {{PBB|geneid=6532}}, which adds in all kinds of neat information, but I couldn't find the gene for PMAT (previously called human equilibrative nucleoside transporter 4 (hENT4)). Anyone know how to do that?

[rocknroll714]

Originally Posted by LostPancake

I was looking up paxil, because I wanted to know if caffeine affected the metabolism of it, but instead wound up adding an article on a relatively newly discovered (2004) monoamine transporter, PMAT.

http://en.wikipedia.org/wiki/Plasma_...ne_transporter

The SSRI's apparently don't affect it much. Another drug target!

I still want to know about the caffeine though - I'll have to pursue it later.

One thing though, for SERT they have a tag at the top {{PBB|geneid=6532}}, which adds in all kinds of neat information, but I couldn't find the gene for PMAT (previously called human equilibrative nucleoside transporter 4 (hENT4)). Anyone know how to do that?

Interesting find! I wonder if it has any significant central effects.

[rocknroll714]

Another article I've been working on and pretty much finished up the other day:

http://en.wikipedia.org/wiki/5-HT1A_receptor

One of my finest works yet! Who wants to help me do the other 5-HT receptor articles?

Also, I got this yesterday:

http://en.wikipedia.org/wiki/User:Rocknroll714#Awards

I'm so proud of myself! :D

[jim_morrison]

In relation to my previous post regarding Mirtazapine and Venlafaxines possible antinociceptive effects at the opioid receptors. I'd like to add, that it's interesting to note that venlafaxine is structurally and pharmacologically related to the synthetic opioid analgesic tramadol, but not to any of the conventional antidepressant drugs. This may also possibly explain why venlafaxines discontinuation syndrome is more severe than that of most of the SSRI's.

[rocknroll714]

Originally Posted by jim_morrison

In relation to my previous post regarding Mirtazapine and Venlafaxines possible antinociceptive effects at the opioid receptors. I'd like to add, that it's interesting to note that venlafaxine is structurally and pharmacologically related to the synthetic opioid analgesic tramadol, but not to any of the conventional antidepressant drugs. This may also possibly explain why venlafaxines discontinuation syndrome is more severe than that of most of the SSRI's.

See this:

5-HT1A Receptor Agonists Cause Profound Analgesia Comparable to High Doses of Opioids.

[jim_morrison]

Originally Posted by rocknroll714

See this:

5-HT1A Receptor Agonists Cause Profound Analgesia Comparable to High Doses of Opioids.

Very interesting article, makes alot of sence since serotonin/norepinephrine are quite effective in the treatment of pain, particularly neuralgia.

I still find it bizarre however that venlafaxine is influenced by the opioid receptor subtypes μ-, κ1- κ3- and the δ-opioid receptor, and mirtazapine @ the μ- and κ3-opioid receptors.

Is it possible that the combination of all 3 - serotonin/norepinephrine/opioid plays a role with drugs like tramadol/venlafaxine etc?

[jim_morrison]

Originally Posted by rocknroll714

Thank you, I'll take a look at it sometime.



I'll take a look at those as well.

Thanks I appreciate it, sorry that I'm not much help with editing wikipedia, but my wording and referencing skills are pretty terrible.

[jim_morrison]

For anyone who's interested in editing wikipedia pharmacology articles, I would highly recommend the book "Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications", you can view most of it for free via google books.

I'm still new to the whole idea of editing wikipedia, and still getting used to the whole referencing part, which limits me a bit.

[db0255]

I wanna do something about personality changes on the Prozac article, rocknroll, how do i do that?

[Vini Vidi Vici]

well personality changes are pretty much a side effect of all SSRIs like prozac zoloft ect.... but it would be good if maybe there was a more defined "side effect" section in the Prozac article. it looks like there is no side effect section. I guess all you would really have to do is Make a new section with the level 2 headline button.....go click the edit button on the top of the page, and push the level 2 headline button with the cursor where you want the "Side Effects" section to be...... the level 2 headline button looks like a big "A" its on the main bar of editing buttons....but u have to include references, which is really a pain because they are so hard to do.

[rocknroll714]

Originally Posted by jim_morrison

Very interesting article, makes alot of sence since serotonin/norepinephrine are quite effective in the treatment of pain, particularly neuralgia.

I still find it bizarre however that venlafaxine is influenced by the opioid receptor subtypes μ-, κ1- κ3- and the δ-opioid receptor, and mirtazapine @ the μ- and κ3-opioid receptors.

Is it possible that the combination of all 3 - serotonin/norepinephrine/opioid plays a role with drugs like tramadol/venlafaxine etc?

Yes, those systems (as well as the dopamine system) are all cross-linked.

[db0255]

Originally Posted by Vini Vidi Vici

well personality changes are pretty much a side effect of all SSRIs like prozac zoloft ect.... but it would be good if maybe there was a more defined "side effect" section in the Prozac article. it looks like there is no side effect section. I guess all you would really have to do is Make a new section with the level 2 headline button.....go click the edit button on the top of the page, and push the level 2 headline button with the cursor where you want the "Side Effects" section to be...... the level 2 headline button looks like a big "A" its on the main bar of editing buttons....but u have to include references, which is really a pain because they are so hard to do.

I disagree. Prozac has shown that in a small portion of users that it transforms their personalities, not like the other SSRIs. It's not a side effect, it's THE effect of Prozac. I haven't heard on account of another SSRI changing a personality like Prozac does. There's books on it too.

[Vini Vidi Vici]

Originally Posted by db0255

I disagree. Prozac has shown that in a small portion of users that it transforms their personalities, not like the other SSRIs. It's not a side effect, it's THE effect of Prozac. I haven't heard on account of another SSRI changing a personality like Prozac does. There's books on it too.

ok my bad. ya i really don't have any hard evidence.... well Paxil sure changed my personality...but i dont really know. I just started Parnate today, so any post of mine might not make sense.