Social Anxiety Support

dronez · 10-26-2009, 07:09 PM

is this combo counteractive?

on this other forum, the girl thinks so...

http://www.mindandmuscle.net/forum/l...hp/t19035.html

I dont really understand all the NMDA talk. what does it all mean!!!!!?

JayJay · 10-26-2009, 08:19 PM

Really don't think the original poster in the linked thread knows what she's talking about. I assume she's looking for a way to reverse tianeptine tolerance. It isn't as easy as just taking piracetam or the people who actually study this would've found that out years ago.

dronez · 10-26-2009, 08:23 PM

do you have any idea about the NMDA thing she is talking about???

I mean, does tianeptine do one thing to my neurotransmitters while piracetam does the opposite? would this be dangerous to have two substances in my brain working oppositely ?

crayzyMed · 10-27-2009, 01:48 AM

Tianeptine isnt an NMDA antagonist and wont interfere with piracetam.

dronez · 10-27-2009, 04:02 PM

wikipedia says it has some sort of effect on NMDA transmission. do you know what mechanism it operates by? how does Tianeptine effect NMDA transmission?

crayzyMed · 10-28-2009, 02:41 AM

Quote:

Originally Posted by dronez

wikipedia says it has some sort of effect on NMDA transmission. do you know what mechanism it operates by? how does Tianeptine effect NMDA transmission?

It modulates some NMDA receptors but i dont think that would interact with piracetam, in my opinion they would work togheter nicely.

Vini Vidi Vici · 10-28-2009, 02:38 PM

NMDA activation can sometimes result in an anxiogenic or depressive effect....the girl was probably worried than piracetam, by activating NMDA, would increase her depression and anxiety, possibly cancelling out any good therapeutic effects that the tianeptine had caused.

crayzyMed · 10-28-2009, 03:33 PM

Quote:

Originally Posted by Vini Vidi Vici

NMDA activation can sometimes result in an anxiogenic or depressive effect....the girl was probably worried than piracetam, by activating NMDA, would increase her depression and anxiety, possibly cancelling out any good therapeutic effects that the tianeptine had caused.

Piracetam causes depression in some ppl, so yeah for some it could be a bad idea to take piracetam.

dronez · 10-28-2009, 04:28 PM

maybe I will go for a lower dose of piracetam - I think I was getting kind depressed taking 3 grams 3 times a day.

speaking of the NMDA thing - I took gabapentin - and that stuff made me feel like wanting to die. I was on tianeptine at the time too. Initially the gabapentin worked well, but on day 2 I got like super depressed.

tianeptine has been working good though by itself - even though it doesnt work for long.

I need the piracetam though because my brain doesnt feel awake a lot of the time and piracetam will do the trick.

euphoria · 10-28-2009, 04:36 PM

I don't think we know enough about either of them yet to say for sure. I'd be wary of boosting NMDA activity, as hyperactivity of NMDA receptors causes neuron death. NMDA receptors are also thought to be involved in drug tolerance (excess activity, that is). Blocking them produces a powerful antidepressant effect, so depression would be another concern for me.

Quote:

Initially the gabapentin worked well, but on day 2 I got like super depressed.

That exact same thing happened to me. Just sucks every positive feeling outta ya.

dronez · 10-28-2009, 04:40 PM

euphoria,

you mean you don't think I should combine piracetam and tianeptine?

which effect does tianeptine have on nmda?

crayzyMed · 10-29-2009, 03:30 AM

Quote:

Originally Posted by euphoria

I don't think we know enough about either of them yet to say for sure. I'd be wary of boosting NMDA activity, as hyperactivity of NMDA receptors causes neuron death. NMDA receptors are also thought to be involved in drug tolerance (excess activity, that is). Blocking them produces a powerful antidepressant effect, so depression would be another concern for me.

That exact same thing happened to me. Just sucks every positive feeling outta ya.

A full NMDA agonist is neurotoxic yes, but NMDA modulators like piracetam are in fact neuroprotective. I even tought that D-Cycloserine hasnt been shown to be neurotoxic even tough its a partial agonist (correct me if i'm wrong on that last one

). D-Cyclosering has been shown to be effective against fear, but i recommend against it because it would speed tolerance to a lot of things.

Piracetam also seems to lower tolerance to various chemicals.

dronez · 10-29-2009, 07:10 PM

I wish there was a nice resource out there for tianeptine combos. I keep reading on line and it says that it decreases AMPA while piractam modulates it. aren't these two substances counteracting in the department?

also someone posted online about tianeptine's effect being reduced by benzos. anyway to validate this? where can I find thorough information about these combos. nothing on the internet breaks it down.

10-26-2009, 07:09 PM	#1 (permalink)
dronez Status: SAS Member Join Date: Dec 2008 Posts: 26	piracetam and tianeptine?? is this combo counteractive? on this other forum, the girl thinks so... http://www.mindandmuscle.net/forum/l...hp/t19035.html I dont really understand all the NMDA talk. what does it all mean!!!!!?

10-28-2009, 02:38 PM	#7 (permalink)
Vini Vidi Vici Status: altruistic philanthropist Join Date: Jul 2009 Location: Minnesota Gender: Male Age: 18 Posts: 289	NMDA activation can sometimes result in an anxiogenic or depressive effect....the girl was probably worried than piracetam, by activating NMDA, would increase her depression and anxiety, possibly cancelling out any good therapeutic effects that the tianeptine had caused. __________________ Please don't take or trust any medical advice from me...Consult a perffessional. meds taken for extended period of time: zyprexa, zoloft, risperdal, klonopin, temazepam, xanax, agomelatine, ambien, adderall, metadate, EMSAM, selegiline, paxil, lexapro, wellbutrin, seroquel, trazodone, clonidine, tramadol, remeron, vyvanse, concerta, Lunesta, Parnate. Current Meds: Parnate 30 mg, Diagnoses- Major Depression, OCD, Social Anxiety, GAD

10-26-2009, 08:19 PM	#2 (permalink)
JayJay Status: SAS Member Join Date: Nov 2003 Posts: 194	Really don't think the original poster in the linked thread knows what she's talking about. I assume she's looking for a way to reverse tianeptine tolerance. It isn't as easy as just taking piracetam or the people who actually study this would've found that out years ago.

10-26-2009, 08:23 PM	#3 (permalink)
dronez Status: SAS Member Join Date: Dec 2008 Posts: 26	do you have any idea about the NMDA thing she is talking about??? I mean, does tianeptine do one thing to my neurotransmitters while piracetam does the opposite? would this be dangerous to have two substances in my brain working oppositely ?

10-27-2009, 01:48 AM	#4 (permalink)
crayzyMed Status: Crazy Member!! Join Date: Nov 2006 Location: Belguim Gender: Male Age: 21 Posts: 390	Tianeptine isnt an NMDA antagonist and wont interfere with piracetam.

10-27-2009, 04:02 PM	#5 (permalink)
dronez Status: SAS Member Join Date: Dec 2008 Posts: 26	wikipedia says it has some sort of effect on NMDA transmission. do you know what mechanism it operates by? how does Tianeptine effect NMDA transmission?

10-28-2009, 04:28 PM	#9 (permalink)
dronez Status: SAS Member Join Date: Dec 2008 Posts: 26	maybe I will go for a lower dose of piracetam - I think I was getting kind depressed taking 3 grams 3 times a day. speaking of the NMDA thing - I took gabapentin - and that stuff made me feel like wanting to die. I was on tianeptine at the time too. Initially the gabapentin worked well, but on day 2 I got like super depressed. tianeptine has been working good though by itself - even though it doesnt work for long. I need the piracetam though because my brain doesnt feel awake a lot of the time and piracetam will do the trick.

10-28-2009, 04:40 PM	#11 (permalink)
dronez Status: SAS Member Join Date: Dec 2008 Posts: 26	euphoria, you mean you don't think I should combine piracetam and tianeptine? which effect does tianeptine have on nmda?

10-29-2009, 07:10 PM	#13 (permalink)
dronez Status: SAS Member Join Date: Dec 2008 Posts: 26	I wish there was a nice resource out there for tianeptine combos. I keep reading on line and it says that it decreases AMPA while piractam modulates it. aren't these two substances counteracting in the department? also someone posted online about tianeptine's effect being reduced by benzos. anyway to validate this? where can I find thorough information about these combos. nothing on the internet breaks it down.