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Old 10-30-2009, 12:43 PM   #1 (permalink)
 
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Default Phenylethylamine(PEA) + selegiline - questions

Hello, I want to ask a few questions about phenylethylamine (PEA) + Selegiline + Carvedilol/NRI combo :

Could you please write me the exact procedure, how to use selegiline with PEA ?

Which PEA dose would be perfect to get a prosocial + AD effect ? Is there inderal or extra Carvedilol necessary? Is there a really big difference on dopamine activity between 5mg Selegiline daily or 10 mg daily?

Do you think it can be a long term solution or just be used recreationally because of short duration of action ?How long is the duration of action or how often do I have to redose in your opinion(including doses please) ? Could you also write me please, how to extend the duration of combo effect ?

What are the side effects of PEA + Selegiline? What could I take to taper off the comedown?

Sorry for all the questions, but I want to know all about this combo and you are quite knowledgeable about it.

Many Thanks

PS: Thank you Euphoria, IllusionalFate for helping out.
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Old 10-30-2009, 01:28 PM   #2 (permalink)
 
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when i used this combo i usually used just the 6mg EMSAM patch, and about 1 gram of PEA, and i almost had a stroke..my blood pressure was 180. i believe the correct way to do it is- 5mg of selegiline, for stronger results, take 5 mg for 2 days before taking PEA. 10mg would probably only make it stronger, and cause a little bit more anxiety. doses as low as 10mg of PEA have been shown to be effective in treating depression....id start as low as you can possibly measure, just to avoid unwanted side effects. Im not familiar with the proper carvedilol dosage...but i believe there is already a whole old thread here on PEA+selegiline, and the proper way to do it and dosages. you could probably get some good information there.it has a whole bunch of cool information...

this combo was really weird for me...it induced a wierd, loving, super pro-social effect, while at the same time, inducing more social anxiety. but the pro-social effects overpowered the anxiety, and i ended up calling all the hot girls i had on my cell phone, leaving wierd messages, or attempting conversation. Interestingly, my social skills were not improved,..only the drive to socialize was maximized.
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meds taken for extended period of time: zyprexa, zoloft, risperdal, klonopin, temazepam, xanax, agomelatine, ambien, adderall, metadate, EMSAM, selegiline, paxil, lexapro, wellbutrin, seroquel, trazodone, clonidine, tramadol, remeron, vyvanse, concerta, Lunesta, Parnate.
Current Meds: Parnate 30 mg,
Diagnoses- Major Depression, OCD, Social Anxiety, GAD
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Old 10-30-2009, 02:18 PM   #3 (permalink)
 
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Danger issues aside, even on selegiline I don't think it'd last long enough to be useful. Popping pills every hour would just make you look weird, and I doubt the police / your employer / teacher / whatever would take too kindly to it. The initial high will disappear over time and you'll get severely depressed after it wears off. You can easily die in one of the most terrible ways possible, or get permanent drain bamage. I can't believe I ever made those threads about PEA.

Carvedilol is also a bad idea. For people without medical training, like you (I assume) or me, dabbling in this stuff is just asking for trouble. PEA has a much shorter half life than carvedilol, so when PEA wears off you'd get a massive drop in blood pressure. I don't think having your BP go up and down like that can possibly be good for the body. Also, it may be an alpha/beta blocker, but does anyone actually know how strongly is affects alpha vs beta receptors? Do you have blood pressure & body temp monitoring equipment? Even with those I'd say it's very risky.

For the record, I didn't help the OP out, I answered a couple of questions but mainly repeatedly warned him of the dangers, and to definitely not try this.
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Old 10-30-2009, 06:09 PM   #4 (permalink)
 
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euphoria's right...its, really, really, coarse. not smooth or predictable at all. nearly every time i took PEA with selegiline, my social anxiety went through the roof. however, it did lessen my depression, and gave me a little bit more motivation. youd have to be super careful...the PEA is really hard to measure if its not in capsules, and when its in capsules its usually in huge doses of like 500 mg. i actually bought a bottle of pure powdered PEA, and i stuck my finger in it, and got the smallest visible speck of powder i could visibly see. And that tiny speck had to be the WORST tasting thing i have ever tasted, it numbs and burns your mouth. but it was worth it when i didn't have anything else, i guess. its would have to be used in conjuction with an anti-anxiety agent, hopefully one that can be used sustainably without tolerance. PEA resembles a small dose of adderral, motivation-wise. But it packs a whole bunch more anxiety that any amount of adderral ever could. i had really high hopes for PEA, it didn't quite live up to the hype, by itself. but taken in conjunction with an SSRI, (paxil for me) it worked really well, the SSRI lessened the anxiety....but PEA has a half life of about 15 minutes. So u have to take selegiline with the SSRI, which is potentially dangerous...i got serotonin syndrome way too many times....not fun
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meds taken for extended period of time: zyprexa, zoloft, risperdal, klonopin, temazepam, xanax, agomelatine, ambien, adderall, metadate, EMSAM, selegiline, paxil, lexapro, wellbutrin, seroquel, trazodone, clonidine, tramadol, remeron, vyvanse, concerta, Lunesta, Parnate.
Current Meds: Parnate 30 mg,
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Old 11-08-2009, 11:56 AM   #5 (permalink)
 
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what do you think about taking 60mg daily in a few divided dosages throughout the day ?
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Old 11-08-2009, 12:54 PM   #6 (permalink)
 
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Quote:
Originally Posted by Vini Vidi Vici View Post
So u have to take selegiline with the SSRI, which is potentially dangerous...i got serotonin syndrome way too many times....not fun
Didn't you use a MAOB selective dose?
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Old 11-08-2009, 02:10 PM   #7 (permalink)
 
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Quote:
Originally Posted by euphoria View Post
Didn't you use a MAOB selective dose?
not exactly....i was using the EMSAM patch...so its impossible to really tell how much you are really getting..and many times i would put on 2 or 3 of the 9mg patches, and apparently the MAO inhibiting effects lasted for a long time. and i was taking Curcumin with Piperine which inhibits MAO-A...i mean of course its an herbal supplement..but based on interactions i had and the feeling i got from it, it was a strong, but short-lived inhibitor or MAO-A. sometimes i would take just a quarter of a pill of lexapro, and i got serotonin syndrome...not side effects, it was seriously serotonin syndrome...like really high fever, tremors, muscle ridgidity, emesis, cognitive impairment and all that stuff. i wasnt thinking very clearly back then...i think all the SSRIs blocked my judgement and reasoning skills.
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Please don't take or trust any medical advice from me...Consult a perffessional.

meds taken for extended period of time: zyprexa, zoloft, risperdal, klonopin, temazepam, xanax, agomelatine, ambien, adderall, metadate, EMSAM, selegiline, paxil, lexapro, wellbutrin, seroquel, trazodone, clonidine, tramadol, remeron, vyvanse, concerta, Lunesta, Parnate.
Current Meds: Parnate 30 mg,
Diagnoses- Major Depression, OCD, Social Anxiety, GAD
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