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Old 07-06-2011, 12:54 PM   #1 (permalink)
 
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Default Phenibut and SSRI

Can Phenibut and an SSRI cause Serotonin syndrome?
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Old 07-06-2011, 02:43 PM   #2 (permalink)
 
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Never. It's safe to take them together.
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Old 07-06-2011, 04:57 PM   #3 (permalink)
 
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Never. It's safe to take them together.
Thanks swim, is there any drug interactions with it that I should worry about?
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Old 07-06-2011, 05:51 PM   #4 (permalink)
 
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I take phenibut from time to time along with my regular fluoxetine - no problem. Phenibut is slightly dopaminergic, but doesn't affect serotonin.
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Old 07-06-2011, 06:58 PM   #5 (permalink)
 
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I take phenibut from time to time along with my regular fluoxetine - no problem. Phenibut is slightly dopaminergic, but doesn't affect serotonin.
Thanks broflovski! Do you know anything that is like Phenibut that can be taken on the "off-days" that is okay with use of ssri's?
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Old 07-06-2011, 07:38 PM   #6 (permalink)
 
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Baclofen is very much alike phenibut. But I prefer kratom. Both are compatible with SSRIs.
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Old 07-06-2011, 08:18 PM   #7 (permalink)
 
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Baclofen is very much alike phenibut. But I prefer kratom. Both are compatible with SSRIs.
Oh thank you! What kind of kratom do you use? I see there are Thai and other kinds.
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Old 07-06-2011, 08:58 PM   #8 (permalink)
 
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You know, kratom must be used only occasionally not to develop tolerance. I use Indo (Indonesian?) reduced leaves, that are reported to be balanced in stimulating/calming effects, while Thai is more energizing and is traditionally used for physical labor.
I would take something like diazepam occasionally in rotation with kratom and phenibut (this one more regularly)... but I have no prescription.
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Old 07-06-2011, 10:33 PM   #9 (permalink)
 
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Thanks swim, is there any drug interactions with it that I should worry about?
do not take 5-htp and/or hypericum with ssri
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Old 07-07-2011, 04:01 AM   #10 (permalink)
 
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Originally Posted by broflovski View Post
Baclofen is very much alike phenibut. But I prefer kratom. Both are compatible with SSRIs.
I'd say Baclofen is too much like Phenibut to use on 'off days'. Baclofen is p-Cl-phenibut after all. They are both GABA-b agonists and taking them for more than a couple of days a week will lead to tolerance (more so of Phenibut) and awful withdrawn when stopped.

I've been using Baclofen as an alternative to Phenibut but strictly still only 2 days a week.
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Old 07-07-2011, 04:41 AM   #11 (permalink)
 
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Thanks broflovski! Do you know anything that is like Phenibut that can be taken on the "off-days" that is okay with use of ssri's?
Pregabalin is somewhat like Phenibut in effect (as it raises GABA levels) and can be taken with SSRI's. It's really just sedating meds/drugs that could have negative interactions with Pregabalin.

However, always make sure you do your research with regards to interactions with the particular SSRI you are on with anything else you decide to start taking.
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Old 07-07-2011, 04:53 AM   #12 (permalink)
 
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Pregabaline is nice, but I took it only once. It shouldn't interact with SSRI pharmacologically, but kinetics interactions must be considered for all substances taken.
Pregabaline may be addictive too.
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Old 07-07-2011, 05:48 AM   #13 (permalink)
 
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Pregabalin is somewhat like Phenibut in effect (as it raises GABA levels)
I thought pregabalin was stronger than phebibut, although I once took a pill of 100mg gabapentin and felt almost nothing.
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Old 07-07-2011, 07:40 AM   #14 (permalink)
 
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What does kratom effect? I read that it was a psychedelia type of drug. Do you know what it chemically does?
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Old 07-07-2011, 07:43 AM   #15 (permalink)
 
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I thought pregabalin was stronger than phebibut, although I once took a pill of 100mg gabapentin and felt almost nothing.
I guess it depends on what dosage you take. I take 150mg Pregabalin and feel quite nice, calm and pretty relaxed all day. It's weaker than the 2g Phenibut dose I take, but that's fine as I take Pregabalin and go to work.
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Old 07-07-2011, 07:45 AM   #16 (permalink)
 
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Pregabaline may be addictive too.
Yeah again like Phenibut it's best kept PRN or cycled. That's pretty much the rule for most GABAergic meds/drugs.
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Old 07-07-2011, 09:07 AM   #17 (permalink)
 
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Any suggestions for a starting dose on phenibut?
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Old 07-07-2011, 10:02 AM   #18 (permalink)
 
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Any suggestions for a starting dose on phenibut?
try 500mg first, wait 2 hrs if nothing try another 250mg. I started to notice a little bit at 750mg, now I'm up to 1G and its quite nice.
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Old 07-07-2011, 10:03 AM   #19 (permalink)
 
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Any suggestions for a starting dose on phenibut?
Take 500mg-1g at first to see how you get on with it, and if you don't have any adverse reaction to it, then try 2g next time. 2g is the dose the most people feel Phenibuts full effects at.

I takes about 1-2hrs for any effects to become apparent in my experience, but it then lasts a very long time. 12hrs is common. Some times I'll take it at 8am in the morning and feel it strongest at 7pm that evening. Due to it's effects longevity, beware of taking more within that time frame, as it may just make you fall asleep. (It's very like GHB in that respect)

Bear in mind though that some people feel nothing, even with high doses. Or it just gives them a headache, makes them nauseous, or sleepy. It is often used as a sleep aid after all so you can take it, go to sleep, then wake up feeling great!

2g is also a sensible dose to stick to, as taking more will increase the chance of tolerance if done too often. Also don't take it for more than a couple of days in a row, as you'll risk a nasty withdrawal if you take it for too many consecutive days, and also risk Phenibut tolerance, which some people never recover from. I feel a 5 day wash out between taking it works well, and i've been taking it for a year now and it's still effective. It poops out on a lot of people, but that may well simply be down to it being used too much by them.
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Old 07-07-2011, 10:20 AM   #20 (permalink)
 
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Quote:
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Yeah again like Phenibut it's best kept PRN or cycled. That's pretty much the rule for most GABAergic meds/drugs.
Yeah but phenibut is far worse then all the rest, with benzo's having a horrid withdrawal and GHB the hardest to get addicted too.
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