Yesterday, I started taking Perika (WS 5570), a high-quality SJW formulation by Nature's Way. Supposedly, this is the best formulation (maybe along with Kira), because it contains a standardized extract with large amounts of hyperforin, the main active ingredient in SJW and a monoamine reuptake inhibitor of serotonin, norepinephrine, dopamine, GABA, and and glutamate. It seems to have a slightly different mechanism of action than SSRIs, and clinical trials have confirmed it has higher efficacy, a much lower side effect profile, and a higher rate of remission than Paxil! Only a tricyclic antidepressant outperformed it in one study, and not significantly.
Paxil vs. WS 5570 comparison in one study for moderate to severe depression: http://www.bmj.com/content/330/7490/503.abstract
Has anyone tried Perika--or any other high-quality
SJW formulation like SC27, Kira, or HBC Protocols, not any old formulation (very important)--with good results? Furthermore, did you supplement with anything else at the time? I'm particularly interested in the efficacy of SJW for atypical depression, which I suspect most of us social phobics with depression have (increased sleeping, sometimes increased appetite with carb/sweet cravings, very low energy/motivation, worsening at night, etc.).
Before anyone says this should be in the supplement section, SJW is a prescription drug in many (most?) countries and as it has similar efficacy to American prescription drugs like Paxil, I believe it should stay in this section, if only so it's taken more seriously.