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Old 10-28-2009, 05:24 PM   #1 (permalink)
 
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Default Paxil: miracle drug?

Hello all. After about 5 months of being med-free, I'm starting up Paxil tomorrow. I've done some research and have read a lot of mixed reviews...but I'm still curious. I know it's different for everyone but, can anyone tell me what I can expect?

And oh yeah, the weight-gain issue...
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Old 10-28-2009, 07:05 PM   #2 (permalink)
 
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I haven't gained a pound

I've tried a lotta stuff n Paxil seems to be top dog.... in my opinion anyway.
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Old 10-28-2009, 07:06 PM   #3 (permalink)
 
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Paxil made me jittery, gave me electric shock sensations, and more nervous but thats just me.
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Old 10-28-2009, 07:18 PM   #4 (permalink)
 
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I was on Paxil and it didn't work for me but that doesn't mean it won't work for you.
I experienced slight weight-gain (not sure if it was paxil related or not)

Oh yeah, and when I started tapering off I got these real GNARLY flu like symptoms. People refer to it as the 'Paxil Flu'. Google it
Anyway, prior to when I started discontinuing the drug I hadn't been sick for years, literally. Coincidence? I think not!
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Old 10-28-2009, 08:01 PM   #5 (permalink)
 
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Originally Posted by Cutegirl View Post
I was on Paxil and it didn't work for me but that doesn't mean it won't work for you.
I experienced slight weight-gain (not sure if it was paxil related or not)

Oh yeah, and when I started tapering off I got these real GNARLY flu like symptoms. People refer to it as the 'Paxil Flu'. Google it
Anyway, prior to when I started discontinuing the drug I hadn't been sick for years, literally. Coincidence? I think not!
It's apparently similar to heroin withdrawal but lasts longer.

I've never been good with taking them everyday and often miss doses. Looks like a bumpy road ahead
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Old 10-28-2009, 10:05 PM   #6 (permalink)
 
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Quote:
Originally Posted by Cutegirl View Post
Oh yeah, and when I started tapering off I got these real GNARLY flu like symptoms. People refer to it as the 'Paxil Flu'. Google it
Anyway, prior to when I started discontinuing the drug I hadn't been sick for years, literally. Coincidence? I think not!
I had the same thing when I started taking it. After three days at 20mg, I couldn't handle it any longer, I felt like complete ****.

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Originally Posted by clandestine View Post
It's apparently similar to heroin withdrawal but lasts longer.

I've never been good with taking them everyday and often miss doses. Looks like a bumpy road ahead
If you miss a dose and feel withdrawal symptoms start to kick in, then take it and the bothersome effects will go away pretty quickly. SSRIs are also good to take at night, so it may be easier for you to remember if you take your daily dose right before bedtime.
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Old 10-29-2009, 09:47 AM   #7 (permalink)
 
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i don't know why, but paxil seemed to work really well for social anxiety for me. it eliminated alot of the anxiety, but it didnt really give me all that much social drive increase all the time. it dulled my perceptions, but other than that it worked. its not perfect, just like all the other SSRIs, but it works and if youre willing to put up with it.... i took DLPA (d l phenylalanine) with it to counteract some of the apathy and low motivation, and i thought it was a really nice combination.
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meds taken for extended period of time: zyprexa, zoloft, risperdal, klonopin, temazepam, xanax, agomelatine, ambien, adderall, metadate, EMSAM, selegiline, paxil, lexapro, wellbutrin, seroquel, trazodone, clonidine, tramadol, remeron, vyvanse, concerta, Lunesta, Parnate.
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Old 10-29-2009, 11:06 AM   #8 (permalink)
 
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Quote:
Originally Posted by Vini Vidi Vici View Post
i don't know why, but paxil seemed to work really well for social anxiety for me. it eliminated alot of the anxiety, but it didnt really give me all that much social drive increase all the time. it dulled my perceptions, but other than that it worked. its not perfect, just like all the other SSRIs, but it works and if youre willing to put up with it.... i took DLPA (d l phenylalanine) with it to counteract some of the apathy and low motivation, and i thought it was a really nice combination.
Now if you only added low-dose selegiline to turn the phenylalanine into something that feels like methamphetamine, then that'd be a killer cocktail.
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Old 10-29-2009, 11:43 AM   #9 (permalink)
 
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5 or 10 mg would be aq better starting dose for an anxiety sufferer
despite heavy promotion as a SA cure its realy just another prozac type med
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Old 10-29-2009, 02:06 PM   #10 (permalink)
 
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5 or 10 mg would be aq better starting dose for an anxiety sufferer
despite heavy promotion as a SA cure its realy just another prozac type med
Hmm. I'm starting at 25mg. I guess I'll give it an honest try, but prozac proved to be pretty much useless for me in the past.
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Old 10-29-2009, 02:07 PM   #11 (permalink)
 
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Quote:
Originally Posted by Vini Vidi Vici View Post
i don't know why, but paxil seemed to work really well for social anxiety for me. it eliminated alot of the anxiety, but it didnt really give me all that much social drive increase all the time. it dulled my perceptions, but other than that it worked. its not perfect, just like all the other SSRIs, but it works and if youre willing to put up with it.... i took DLPA (d l phenylalanine) with it to counteract some of the apathy and low motivation, and i thought it was a really nice combination.
It dulled your perceptions how?
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Old 10-29-2009, 02:23 PM   #12 (permalink)
 
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Quote:
Originally Posted by arth67 View Post
5 or 10 mg would be aq better starting dose for an anxiety sufferer
despite heavy promotion as a SA cure its realy just another prozac type med
It is indeed an SSRI, but there are significant variances among them. Some don't even selectively target the 5-HT system, like sertraline, which weakly inhibits the reuptake of dopamine.

Let's look at a few key differences between fluoxetine and paroxetine:
  • Paroxetine is a more potent anticholinergic
  • Paroxetine is a P-glycoprotein substrate
  • Paroxetine reaches peak plasma concentration ~5 hours after dosing
  • Fluoxetine takes weeks of continuous dosing before maximum plasma levels are reached
  • Fluoxetine and its active metabolite are inhibitors of the isoenzyme CYP2D6
  • Fluoxetine is a 5-HT2C antagonist
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