parnate

[db0255]

just got a prescription for parnate. after a trek to 4 different pharmacies, i finally got it filled. it's 930 pm...too late to take the first one tonight?

[BusterBluth]

I anticipate you will be keeping this thread updated regularly, even if you shed your SA , and, accordingly, I will be be following it closely. All the best, BB

[korey]

Parnate is quite stimulating, so you should probably wait until tomorrow morning before taking your first dose.

[db0255]

Originally Posted by BusterBluth

I anticipate you will be keeping this thread updated regularly, even if you shed your SA , and, accordingly, I will be be following it closely. All the best, BB

Of course. How'd you know BB? You're my favorite dude on here, no homo. I'll keep it updated.

[meyaj]

I'd really love to hear how this works out for you

[IllusionalFate]

I would space the doses out throughout the day, that way you reap all the benefits of its acute dopamine release.

[db0255]

So far just increased anxiety....

[Vini Vidi Vici]

yeah at first it makes you feel like crap. it took a couple days for the weird feeling to go away....probably just the same as the weird feeling when starting SSRIs. something ive been wondering about: since Parnate has a half life of about 2.5 hours (according to wikipedia)....does that mean if one wanted to acheive more MAO inhibition (by taking more than one 10mg tablet) youd have to take all the tablets at once? because if you take them spaced out throughout the day, only a small brain level would be maintained, but its the high acute level that determines the amount of MAO inhibition? if it permanetly destroys MAO

[db0255]

Originally Posted by Vini Vidi Vici

yeah at first it makes you feel like crap. it took a couple days for the weird feeling to go away....probably just the same as the weird feeling when starting SSRIs. something ive been wondering about: since Parnate has a half life of about 2.5 hours (according to wikipedia)....does that mean if one wanted to acheive more MAO inhibition (by taking more than one 10mg tablet) youd have to take all the tablets at once? because if you take them spaced out throughout the day, only a small brain level would be maintained, but its the high acute level that determines the amount of MAO inhibition? if it permanetly destroys MAO

I think the general consensus is that the half life doesn't matter because MAO is inhibited for 2-3 weeks until you regenerate new enzymes. So unless you're underdosing in general, you wouldnt' see a difference other than side effects, etc. from the presence of more parnate.

[IllusionalFate]

Originally Posted by db0255

I think the general consensus is that the half life doesn't matter because MAO is inhibited for 2-3 weeks until you regenerate new enzymes. So unless you're underdosing in general, you wouldnt' see a difference other than side effects, etc. from the presence of more parnate.

You can play around with your dosing schedule however you'd like without altering MAO inhibition, as long as the total daily dose remains the same. I didn't notice any difference (besides the time of day certain side effects appeared, like phenelzine-induced somnolence) in how I structured my dose when I was on Nardil and selegiline.

[db0255]

Definitely is doing something, what that is, I'm not sure yet....

Side effects: Non-existent...I feel more awake, no craving to sleep the day away...Random bouts of anxiety throughout the day is the only thing, but hardly crippling at all.

Stimulating effects Wish I could say it was like having cocaine run through your body...except for the fact that I've never done cocaine. Parnate feels like a caffeinated soda 24/7, although it's not at all hard to go to sleep.

Price Cheap as ****...seriously, it cost me 10 dollars.

I am slowly getting over the fear that anything I eat will secretly have high amounts of tyramine...lol. Although this severely curtails my love for snacking on chocolate, cheese, cookies, etc.

[db0255]

Anybody notice any hypnagogic sensory things on an MAOI? Never heard it talked about, and I definitely notice it. From what I gather, this wouldn't be far from normal considering MAOIs inhibit breakdown of DMT, and other weird chemicals like that?

[Vini Vidi Vici]

did you get the generic version? if so, do you know what company manufactures it? (i.e. Teva, GSK)... i got the name brand because i thought the generic wouldnt work. if the generic works for you then i think im gonna try it because name brand is way to expensive, and my insurance doesn't cover name brand.

[Vini Vidi Vici]

if by hypnagogia you mean paranoia, and over-stimulation by sounds and visual images...i got that too. actually now that i think about it i do have a whole bunch of obvious changes/disturbances in my visual fields. i attributed it to Xanax withdrawal, but apparently it could be from Parnate. i sometimes see like dark flashes/weird stuff, and my sight gets muddled...like im sort of barely asleep, or similiar to when i stay up for extended periods of time.

[db0255]

Originally Posted by Vini Vidi Vici

did you get the generic version? if so, do you know what company manufactures it? (i.e. Teva, GSK)... i got the name brand because i thought the generic wouldnt work. if the generic works for you then i think im gonna try it because name brand is way to expensive, and my insurance doesn't cover name brand.

Generic from Par.

Try the generic....why not, i mean the only thing that I think affects whether generic works for you or not, is if the half-life is longer, and having a steady dose of the medication is necessary...getting generic prozac, made me feel like ****, but i get generic ativan and i'm fine. so i think it working has more to do with the longer the medication acts and bioavailability

[IllusionalFate]

Originally Posted by db0255

Generic from Par.

Try the generic....why not, i mean the only thing that I think affects whether generic works for you or not, is if the half-life is longer, and having a steady dose of the medication is necessary...getting generic prozac, made me feel like ****, but i get generic ativan and i'm fine. so i think it working has more to do with the longer the medication acts and bioavailability

...except bioavailability and half-life are both properties of the chemical compound, not the inactive ingredients. I can't see any reason why a brand name medication would work for someone but not the generic, unless it's a time-release formulation.

[db0255]

Originally Posted by IllusionalFate

...except bioavailability and half-life are both properties of the chemical compound, not the inactive ingredients. I can't see any reason why a brand name medication would work for someone but not the generic, unless it's a time-release formulation.

All I know is that generics have to hit a range of bioavailabilities, and brand names are spot on. Prozac worked for me, but the generic gave me way more side effects and apathy. Bioavailability, from what I've seen, can be changed drastically by inert ingredients, i.e. they might change absorption rates. And the half-life concept, would just apply to how vulnerable the compound is to a changing bioavailability. If the half-life is small, then there wouldn't be that much chance for effing things up, if the half-life is large, then it's a bit different.

When I asked a pharmacist, he said he had never heard anyone have a problem with generic Paxil (short half-life), but a lot more complained about generic Prozac (large half-life). So, I don't know...just my two cents.

[Vini Vidi Vici]

Originally Posted by db0255

All I know is that generics have to hit a range of bioavailabilities, and brand names are spot on. Prozac worked for me, but the generic gave me way more side effects and apathy. Bioavailability, from what I've seen, can be changed drastically by inert ingredients, i.e. they might change absorption rates. And the half-life concept, would just apply to how vulnerable the compound is to a changing bioavailability. If the half-life is small, then there wouldn't be that much chance for effing things up, if the half-life is large, then it's a bit different.

When I asked a pharmacist, he said he had never heard anyone have a problem with generic Paxil (short half-life), but a lot more complained about generic Prozac (large half-life). So, I don't know...just my two cents.

cool. i briefly considered letting the Parnate dissolve in my mouth to bypass any problems with bioavailability, but i will not bother with that anymore.

[BusterBluth]

Originally Posted by db0255

Anybody notice any hypnagogic sensory things on an MAOI? Never heard it talked about, and I definitely notice it. From what I gather, this wouldn't be far from normal considering MAOIs inhibit breakdown of DMT, and other weird chemicals like that?

I noticed some hypnagogic/sleep paralysis type stuff on occasion when I first started Strattera. They became less frequent and then went away completely after the first 3 months. The only good thing was that the WTF-anxiety went away in a couple minutes after I realized I was OK.

[IllusionalFate]

Originally Posted by db0255

All I know is that generics have to hit a range of bioavailabilities, and brand names are spot on. Prozac worked for me, but the generic gave me way more side effects and apathy. Bioavailability, from what I've seen, can be changed drastically by inert ingredients, i.e. they might change absorption rates. And the half-life concept, would just apply to how vulnerable the compound is to a changing bioavailability. If the half-life is small, then there wouldn't be that much chance for effing things up, if the half-life is large, then it's a bit different.

When I asked a pharmacist, he said he had never heard anyone have a problem with generic Paxil (short half-life), but a lot more complained about generic Prozac (large half-life). So, I don't know...just my two cents.

Both generic pills and capsules are completely dissolved after ingestion, so the active chemical compound should be equally available for absorption.

Q: Are generic drugs as strong as brand-name drugs?
A: Yes. The FDA requires generic drugs to have the same quality, strength, purity and stability as brand-name drugs.

* http://www.fda.gov/Drugs/EmergencyPr.../ucm134451.htm