Nardil/Adrenergic antagonism + ideas

[gilmourr]

So last time I was on Nardil, I went up to 75 mg (stayed there for only 1 week) but I was on 60 mg for about 4 weeks.

Once I hit 75 mg I had a REALLY tough time sleeping, peeing was difficult, constipated and I was really tired + orthostatic hypotension.

I'm curious, will a stimulant (raises NE and D) help with the urinary retention and constipation? I read this on wiki (regarding stimulants)..

It also induces contraction of the urinary bladder[7][8], although this effect is minor compared to the relaxing effect of β2-adrenergic receptors. In other words, the overall effect of sympathetic stimuli on the bladder is relaxation, in order to delaymicturition during stress.

According to this, it would help with urination AND definitely with energy+focus and orthostatic hypotension along with hypotensive issues.

Anyways, the whole point of this thread was to ponder, what will happen when I add a stimulant? Don't say death. And don't tell me to just try it and see. I am just wondering in theory. Because I need something to augment all of Nardil's side effects.

[Ben12]

I know I've talked about being on Effexor in the past but when I was on this I was having trouble urinating really badly. It got to the point where it was just intolerable. I can remember being put on a stimulant around the time called Dexedrine. Honestly I can't remember any positive effect from it. It didn't help with the urinary retention at all and just made me irritable. No sense of pleasure or euphoria from it either which I know you can get from this drug. Although I was only on 30mg (15mg twice a day) so I don't know whether that would be a factor or not.

I don't know everyone is different so you might respond differently to a stimulant. But if you are having urinary retention than my advice would be to treat that side effect because I know how intolerable it can be. I would also just say that from past experience a stimulant like Dexedrine would certainly not be primary option for treating such a symptom.

[Inshallah]

Have you found a doctor willing to prescribe them together? I would start there before getting too excited (I know how it is!). You won't find many psychiatrists that are willing to do this/have experience with it.

[gilmourr]

Originally Posted by Inshallah

Have you found a doctor willing to prescribe them together? I would start there before getting too excited (I know how it is!). You won't find many psychiatrists that are willing to do this/have experience with it.

I'll get the stimulant somehow, I'll just go psychiatrist to psychiatrist explaining that Nardil + something in adjunct is worth it. Plus I got referred to I believe the most well known mental health center in our province -- Which is a last resort usually. Someone there MUST have experience with Nardil.

If not, I'll go off Nardil and say I'm ADHD and get it that way.

Plus effexor isn't exactly the same since it adds to your levels of norepinephrine, while for Nardil it seems that my BP is lower. On effexor my BP was like 160/100.

And I don't think there is a point of using a cholinergic med to solve the urinary issue if it comes up because the affinity with Nardil and anti-choline antagonism is non-existent I've heard.

Nardil hits mainly (SERT, NE, D, melatonin, GABA)

[Ben12]

Lol well you certainly know a lot more about medications than me.

[spartan7]

Nardil does not work anymore since 2003 when the drug was reforumulated

[mr t]

Originally Posted by gilmourr

I'll get the stimulant somehow, I'll just go psychiatrist to psychiatrist explaining that Nardil + something in adjunct is worth it. Plus I got referred to I believe the most well known mental health center in our province -- Which is a last resort usually. Someone there MUST have experience with Nardil.

If not, I'll go off Nardil and say I'm ADHD and get it that way.

Plus effexor isn't exactly the same since it adds to your levels of norepinephrine, while for Nardil it seems that my BP is lower. On effexor my BP was like 160/100.

And I don't think there is a point of using a cholinergic med to solve the urinary issue if it comes up because the affinity with Nardil and anti-choline antagonism is non-existent I've heard.

Nardil hits mainly (SERT, NE, D, melatonin, GABA)

When I had urinary retention on 60mg nardil i used Bethanecol.

It prescribed for urinary retention and targets the muscarinic receptors of the bladder and GI tract to make you piss.

"Bethanechol is a powerful cholinergic agent which efficiently crosses the blood - brain barrier and may have powerful nootropic properties in enhancement of neural signaling and processing speed as well."

^^^^Maybe it will also help you with your memory problems you are having!!!!

It is an anticholinergic drug that helped me piss probably 30 mins after i took it. Did the job just fine.

It has no side effects whatsoever when i used it. Very safe drug, no contradictions with nardil.

Urinary retention is a side effect of anticholinergic effects. Even though acetylcholinesterase breaks down ACh instead of MAO, there can still be some anticholinergic effects via other mechanisms from MAOIs

Heres the wikipedia link to bethanecol:

http://en.wikipedia.org/wiki/Bethanechol

If that doesnt work for your urinary retention, you could always use a low dose of Flomax.

hope this helps!!