Med wishlist 2012

[Dr House]

What medications would you like to try for 2012 which you think you might have some chance in hell of getting prescribed or acquiring?

My two picks are Lamictal or Seroquel XR for my unstable moods/chronic unipolar depression that seems to be treatment resistant to regular anti-depressants. I may even be able to get off these anti orgasm SSRI pills altogether too! woot!

[laura024]

I hated Seroquel. I want anything that's going to help my anxiety and mania.

You might respond well to Neurontin. It has very minimal side effects. It took away my depression.

[Dr House]

Originally Posted by laura024

I hated Seroquel. I want anything that's going to help my anxiety and mania.

You might respond well to Neurontin. It has very minimal side effects. It took away my depression.

I've tried Neurontin before, but never on a consistent basis and never intended to target my depression with it. What dosing schedule did you use for it for depression?

I am on Lyrica, but it causes a LOT of cognition problems that I can't really tolerate, so thus I don't use it as often as I am allowed to.

Just because Seroquel IR didn't work doesn't mean Seroquel XR won't. The two seem to have very different effects compared to what you would expect for both being Seroquel from what I've heard. I want to see it for myself the difference between the two.

[laura024]

Originally Posted by Dr House

I've tried Neurontin before, but never on a consistent basis and never intended to target my depression with it. What dosing schedule did you use for it for depression?

I am on Lyrica, but it causes a LOT of cognition problems that I can't really tolerate, so thus I don't use it as often as I am allowed to.

Just because Seroquel IR didn't work doesn't mean Seroquel XR won't. The two seem to have very different effects compared to what you would expect for both being Seroquel from what I've heard. I want to see it for myself the difference between the two.

I started out at 300mg daily. Now I'm taking that twice daily.

Sorry, I didn't specify. I was on Seroquel XR. It's worth a try. I just had too many bad side effects and 200mg sent me into a manic rage.

[JohnG]

Lamictal XR

[metamorphosis]

How about some medications that actually work and don't have a nasty side effect profile (Nardil, Parnate) to boot! I know that's asking for waaayyyy to much in this day in age!!!

Okay, so how about a new sublinqual> why not?, form of MDMA. One that is actually neuroprotective, causes no serotonin rebound and actually has no side effects, except for loving that stranger next to you and believing that humans and humanity, as a whole, are not a huge group of narcassitic *******s, as thought but genuinely care about others. Expressing this love, kindness, and compassion towards one another through group hugs and gropes, non-stop communal dancing and some annoying tekstyle music playing all day and night.
Also this Nü-Fred MDMA comes in a"semi-epic"12 hrs dose without any valleys, just a steady peak. Or the "epic" 24 hr. dose that comes with a free Belgium tekstyle vinyl LP and free passes to a D.J. Twitchy house party. All of this available legally worldwide without a prescription!!!

[swim]

Originally Posted by metamorphosis

Okay, so how about a new sublinqual> why not?, form of MDMA. One that is actually neuroprotective, causes no serotonin rebound and actually has no side effects, except for loving that stranger next to you and believing that humans and humanity, as a whole, are not a huge group of narcassitic *******s, as thought but genuinely care about others. Expressing this love, kindness, and compassion towards one another through group hugs and gropes, non-stop communal dancing and some annoying tekstyle music playing all day and night.
Also this Nü-Fred MDMA comes in a"semi-epic"12 hrs dose without any valleys, just a steady peak. Or the "epic" 24 hr. dose that comes with a free Belgium tekstyle vinyl LP and free passes to a D.J. Twitchy house party. All of this available legally worldwide without a prescription!!!

[metamorphosis]

Originally Posted by swim

The thread is about our wishlist for drugs in 2012. That is the one I want. Is that to much to ask for? All we need is love and a pill to abolish our SAD and inner, toxic shame from childhood. And our depression while we're at it. So, that is my X pill. I think it's doable. I wonder which pharma. is gonna "drop" it.

[baranok]

i would like Psilocybin in pills, on prescription instead of SSRI/benzo

[euphoria]

• Glycine transporter 1 inhibitors
• Selective dopamine reuptake inhibitors
• Selective 5-HT2C antagonists
• Some kind of endogenous opioid catabolism inhibitor, e.g. enkephalinase inhibitor
• Nonbenzodiazepines that are highly selective for anxiolytic GABA receptor types and cause zero cognitive impairment
• 5-HT1A full agonists
• Oxytocinergics
• Kappa opioid receptor antagonists
• Serotonin-dopamine reuptake inhibitors also possessing low but significant 5-HT1A and D2/3 receptor antagonism, working only presynaptically to give a faster and possibly enhanced response
• Intelligently designed combination pills, probably time-released varying for each ingredient, bringing together several synergistic meds rather than trying to design one "perfect compound".
• Anticonvulsant and antimanic drugs that don't make you feel retarded and horrible. Lamictal may be one of the best of a bad bunch but it's still ****. I have to take a benzo for seizures because the usual anticonvulsants make me want to die. And antipsychotics that don't make you so emotionless and dysphoric there's very little reason to even exist any more.

Most important would be effective tolerance-preventing drugs, and a lot of research into that area. 'cause we already have happy pills, the reason they aren't much of a "cure" is tolerance. NMDA antagonists suck, they don't count.

In the world of research chemicals it would be cool to see a selective 5-HT2A agonist psychedelic with no affinity for other receptor subtypes, especially 2C - if such a thng doesn't already exist. Maybe a psychedelic with little to no anxiety potential could make for some awesome therapy sessions if picked up for medical use...


Not been following the world of meds much or learning about pharmacology, but those would be on my wish list.

[jim_morrison]

Originally Posted by euphoria

• Some kind of endogenous opioid catabolism inhibitor, e.g. enkephalinase inhibitor

Would you consider D-phenylalanine for this, or is it too weak?

[UltraShy]

Originally Posted by Dr House

My two picks are Lamictal or Seroquel XR for my unstable moods/chronic unipolar depression that seems to be treatment resistant to regular anti-depressants.

I'm confused by the highlighted part.

Wouldn't chronic unipolar depression mean feeling down consistently? That sounds pretty stable, as opposed to bipolar ups & downs.

-Lamictal = sugar pill, but having no side effects already beats most stuff I've taken that only did bad things.

-Seroquel XR = Never tried the XR version. The regular version is already quite enough to keep me in bed for 15 hours only to wake up ready for a nap. Could cure my problems as you don't have any problems when unconscious. My brother used to go with that method. A liter of whiskey & 400 mg Seroquel and he could sleep life away.

[jonny neurotic]

O-desmethyltramadol is a must. My research chemical supplier is out of stock(only just got it in stock). I will hopefully be purchasing some in the next month or so. I would like to combine this with fluoxetine and ethylphenidate.

In the mean time I will be experimenting with a combo of aMT and ziprasidone. I think this combo will be very similar to MDMA. Lots of serotonin 1A activity and the 2A antagonism will stop the hallucinogenic effects of the aMT. The other effects of ziprasidone should modulate the aMT nicely.

I don't plan on overdoing the dopamine so I will not be using any NMDA antagonists for anything other than recreation(effing luv'em). I think that dopamine releasing agents are more likely to cause D2 downregulation than reuptake inhibitors. I think that you people who are on amps would proly be better, in the long run, on methylphenidate or something similar. I think that serotonin 2C antagonism in combination with dopamine reuptake inhibition would be the best thing for SA...

[euphoria]

Originally Posted by jim_morrison

Would you consider D-phenylalanine for this, or is it too weak?

Since reading this I kind of went off the idea

http://bit.ly/xbUltO

"Phenylalanine carboxypeptidase A is probably not something to inhibit because it's involved in so many other important things like digestion, regulation of angiotensin and neurological function (CPA6 k/o causes seizures).

I think F binds to CPA with a Km in the millimolar or tens of millimolar range... I'm not sure how much you'd have to take to strong inhibit it, but it's probably a whole lot.

And it's best not to be dependent on self-medicated drugs, even if they're legal. D-phen is pretty weak yeah, it'd be good to have a highly specific "booster" of endogenous opioids in legit medical use that can be prescribed.

[euphoria]

Originally Posted by jonny neurotic

O-desmethyltramadol is a must. My research chemical supplier is out of stock(only just got it in stock). I will hopefully be purchasing some in the next month or so. I would like to combine this with fluoxetine and ethylphenidate.

In the mean time I will be experimenting with a combo of aMT and ziprasidone. I think this combo will be very similar to MDMA. Lots of serotonin 1A activity and the 2A antagonism will stop the hallucinogenic effects of the aMT. The other effects of ziprasidone should modulate the aMT nicely.

I don't plan on overdoing the dopamine so I will not be using any NMDA antagonists for anything other than recreation(effing luv'em). I think that dopamine releasing agents are more likely to cause D2 downregulation than reuptake inhibitors. I think that you people who are on amps would proly be better, in the long run, on methylphenidate or something similar. I think that serotonin 2C antagonism in combination with dopamine reuptake inhibition would be the best thing for SA...

Aren't you concerned about neurotoxicity, taking a serotonin + dopamine releasing agent daily? I would at least take preventative measures, like a wide variety of antioxidant supplements.

[blakeyz]

Originally Posted by Dr House

What medications would you like to try for 2012 which you think you might have some chance in hell of getting prescribed or acquiring?

My two picks are Lamictal or Seroquel XR for my unstable moods/chronic unipolar depression that seems to be treatment resistant to regular anti-depressants. I may even be able to get off these anti orgasm SSRI pills altogether too! woot!

SEROQUEL
SEROQUEL XR
Good for sleeping........XR not as strong but can still induce a 8 hour coma
I have tried alot of legal and some illigal drugs and a 300mg seroquel tablet is the biggest knock me the **** out thing i have tried lol

[DubnRun]

I would like to try...zero meds. Seriously all meds are just bad. waste of time. unhealthy. Why not just strip out all manner of junk from your diet and eat no gluten, no fructose, watch sugar intake..and eat lots of organic fruit and veg. Just my opinions anyway.. Better than any meds..

[Unkn0wn Pleasures]

Speed

[DubnRun]

Ganjaaa

[jim_morrison]

Originally Posted by blakeyz

SEROQUEL
SEROQUEL XR
Good for sleeping........XR not as strong but can still induce a 8 hour coma
I have tried alot of legal and some illigal drugs and a 300mg seroquel tablet is the biggest knock me the **** out thing i have tried lol

Yeah I know what you mean about the XR version not being as strong, If I take a 150mg tablet of XR it won't put me to sleep, but yeah the same dose of the original Seroquel was pretty sedating by comparison.