I've had some people ask about my experiences with this drug, when I go on it. Right *now* what I have to say is concerning my pre-medication research and findings. I haven't taken it yet, but here is some information on Parnate (tranylcypromine) and on MAOIs in general.
I would encourage people to independently check anything I say about MAOIs. (Or any drug, really.)
First, two relevant abstracts:
J Clin Psychopharmacol. 1988 Aug;8(4):279-83.
Tranylcypromine in social phobia.
Versiani M, Mundim FD, Nardi AE, Liebowitz MR.
Department of Psychiatry, Federal University of Rio de Janeiro, Brazil.
Thirty-two patients meeting DSM-III criteria for social phobia entered a 1-year drug treatment with tranylcypromine in dosages between 40 and 60 mg/day. After exclusion of the early dropouts, improvement was rated as marked and moderate in 62% and 17% of the sample (N = 29), respectively. Alcohol abuse was associated with a poor outcome. Side effects were frequent and in some cases delayed the attainment of efficacious dosages until the third month of treatment. No serious adverse reactions occurred. The findings, relative to efficacy, are in accordance with a previous trial with phenelzine but need confirmation in double blind controlled studies.
J Psychiatr Res. 1988;22 Suppl 1:87-98.
Monoamine oxidase inhibitors in anxiety disorders.
Tyrer P, Shawcross C.
Mapperley Hospital, Nottingham, U.K.
Monoamine oxidase inhibitors (MAOI's) have been shown to be significantly superior to placebo in the treatment of some anxiety disorders, particularly agoraphobia and mixed anxiety--depressive states. There is no convincing evidence that MAOI's are effective treatment in pure anxiety states, whether or not panic is present as a major symptom, although they are effective in so-called endogenous anxiety. Many past published studies of MAOI's have yielded poor results because the drugs have been prescribed for insufficient time (less than four weeks) or at too low dosage. There are no important therapeutic differences between the MAOI's apart from the faster speed of response with the nonhydrazine compound, tranylcypromine. Treatment often has to be long-term, and some degree of pharmacological dependence may develop. A few clinical studies have compared the efficacy of MAOI's and tricyclic antidepressants in anxious disorders. There is growing evidence that MAOI's are somewhat more effective than tricyclic antidepressants in the treatment of anxiety disorders and when phobic anxiety is an important component of a depressive disorder.
Originally Posted by apprentice1
about Thorazine as an anti-dote for hyper-tension. I am sorry, I posted a stupid post, what can I say? I will edit it to at least take out my "doctor myself" remedy. It is just that I was "treated" with thorazine when I was 22. What size tablet did he give you if I can ask? What you said made sense.
I can understand the Thorazine concern - it's definitely a hardcore medication. I don't have a Rx in my hand for Parnate or for Thorazine yet, I have to wash out from the Wellbutrin first and then meet again with my psychiatrist April 11th.