Marijuana

[crayzyMed]

Originally Posted by ippa

what u describe while u are high is complete mirror of me without even being high on something, i think about such thoughts whenever im near the people im not comfortable with.

I used to be like that 3 years ago, MJ just reverses me back to how i was back then, very ****ty drug, dont use it!! If you make any progress on your anxiety this crap will just reverse it.

[StevenGlansberg]

Smoked again yesterday and it wasn't really bad at all. I kind of prepared myself for it, was in a good mood, and didn't freak out inside my head like I usually do.

This got me thinking and I'm pretty sure someone else posted something like this. Since I can control where I am and when the rush of anxiety comes on, I can use marijuana to face my SAD head on. Usually I'm caught off guard or in a place where I can't escape when my anxiety appears. But when smoking I can stay at home and surround myself with friends that kind of know my situation.

Maybe I can get a handle on it while I'm high if I do it enough. Maybe I can get used to the feeling and confront those irrational thoughts that come when I'm anxious.

I'm excited.

[euphoria]

Weed can be the catalyst for sublime revelations. Or, especially if you smoke regularly and are naturally anxious, it can bring you down with these recursive, annoying thoughts that are invariably negative. The answer? For me, it's SSRI stoning.

[jim_morrison]

One thing I was remembering last night, was that back in my weed days (a few years ago now) I used to have a different type of experience every time I smoked, it could be anywhere ranging from, extremely anxious bordering on panic attack and depersonalisation, or it could be incredibly happy and euphoric, and able to think and concentrate on such a deep level that I could go in and out of my conciousness at will and recall my dreams (and other things usually laying dormant in my mind) in great detail and anaylise them. Strange drug.

[KurtG85]

The original post is like asking people to describe their experience on 'an antidepressant'; their are 100s of anti depressants most of which will have dramatically different effects on people. The same holds true for strains of pot. Some kinds have resulted in very unpleasant experiences and some very euphoric.

Sorry if it annoys anyone to bring this up but pot is a much, much, much, more responsible drug to use than alcohol (in common sense terms, not capital driven US law terms of course). I know many people who are dead, paralyzed, brain damaged, etc. from alcohol use. The risks of pot use are a joke compared to the dangers of alcohol.

[StPatrick317]

Ok, I have an open-minded doc & he is willing to prescribe it, but it would probably sythentic THC(Marinol or something like that). I've been around the block with meds, ect, therapy etc, so this is why. Treatment-Resistant Depression & Anxiety.

I have never smoked weed. But I know THC is the most psychoactive part, whereas there are lots of Cannibinoid things which are much more relaxing and less likely to cause wierd side effects like THC. This makes the fact that the Federal government(my State is pretty lenient on marijauna) approves THC, but not the other less psychoactive versions seem bizarre & openly stupid.

Anyways, I have no idea whether it will work..probably not, but it's worth a shot. Just wondering what to expect. MJ never really appealed to me because I did have one point in my life with plentiful opportunities to try it for free but didnt care or want to.

1 additional question: The 1 drug that ever worked, after 30+ ones, was Nardil. Unforunately, about 9 months in on 90mg I got hypomania & eventually called myself into a mental hospital. I have had 2 psychiatrists, both of them won't prescribe it for this reason. Would take a 2nd shot on this over marijuana anyday of the week. How would you find a doctor to prescribe this MAOI, considering you have 2 previous ones who wont(& your gonna let this doc know that)?? Just keep going to ones till you find one?

Thanks!

[rocknroll714]

This is semi-off-topic but I thought I'd post anyway:

• Understanding Your High:The Effects Of Marijuana On Consciousness

Really awesome read for anyone interested in marijuana's cognitive effects.

[Thomas Paine]

Originally Posted by rocknroll714

This is semi-off-topic but I thought I'd post anyway:

• Understanding Your High:The Effects Of Marijuana On Consciousness

Really awesome read for anyone interested in marijuana's cognitive effects.

looks like a good article. I bookmarked it to try and read tomorrow. Thanks.

[stealyourface722]

Originally Posted by StPatrick317

Ok, I have an open-minded doc & he is willing to prescribe it, but it would probably sythentic THC(Marinol or something like that). I've been around the block with meds, ect, therapy etc, so this is why. Treatment-Resistant Depression & Anxiety.

I have never smoked weed. But I know THC is the most psychoactive part, whereas there are lots of Cannibinoid things which are much more relaxing and less likely to cause wierd side effects like THC. This makes the fact that the Federal government(my State is pretty lenient on marijauna) approves THC, but not the other less psychoactive versions seem bizarre & openly stupid.

Anyways, I have no idea whether it will work..probably not, but it's worth a shot. Just wondering what to expect. MJ never really appealed to me because I did have one point in my life with plentiful opportunities to try it for free but didnt care or want to.

1 additional question: The 1 drug that ever worked, after 30+ ones, was Nardil. Unforunately, about 9 months in on 90mg I got hypomania & eventually called myself into a mental hospital. I have had 2 psychiatrists, both of them won't prescribe it for this reason. Would take a 2nd shot on this over marijuana anyday of the week. How would you find a doctor to prescribe this MAOI, considering you have 2 previous ones who wont(& your gonna let this doc know that)?? Just keep going to ones till you find one?

Thanks!

if your got hypomanic then just take a bipolar med. what the?? did you try that? THC might make you manic too. it does it to me

[pokeherpro]

Well, I quit for 3 days. I'm disappointed cause I wanted to just quit forever, but I'm realizing it's not going to be that easy. I get soooo bored sometimes, and then I imagine how fun it'd be to get baked...and I can't stop. I'm just going to smoke less than I did before.
I feel so guilty right now.

[StevenGlansberg]

Well after being excited that I could control my anxiety with MJ, I just had one of the worst experiences of my life. It is indescribable. It was so bad I had to shut myself in my room and attempt to sleep it off.

I will never smoke it again.

[Haydsmom2007]

I'm not that interested in it because I feel like it's a huge waste of money. (It's expensive... I don't have money to blow on that...)

but I dunno. It's nice being able to just have that relaxed state of mind. I was really super paranoid at first which made me more anxious but I suppose you just have to deal with that and learn that there's nothing to be paranoid about and then everything is dandy. lol. Yeah, I dunno. I like it. I don't have any SA when I'm high haha... It's hard to explain. when I'm high and I walk through a store and there's people, I just don't get nervous or awkward or anything. I'm just like "heyy man..." and then I don't give a f*ck what they would think of me so I could start up a conversation about any ol' thing.. lol. but yeah, like I said, I don't waste my money on it. 60 bucks aint worth it. There's even this stuff called k-2 that's legal and very similar to weed. It makes you high just the same and it's about half the price. And LEGAL. but it still isn't worth the money to me.

[rocknroll714]

Some stuff I've been looking into lately I thought I'd mention:

• http://docs.google.com/Doc?docid=0AT...ZDNxNWhu&hl=en

* Low-dose THC (0.075-0.75 mg/kg, i.p.) and AM-404 (0.75-1.25 mg/kg, i.p.) produce anxiolytic effects through activation of the CB1 receptor, which then enhances 5-HT1A receptors downstream.
* High-dose THC (2, 6, and 10 mg/kg, i.p.) produces depressive and anxiogenic effects through activation of the CB1 receptor, which then saturates 5-HT1A receptors downstream.
* These data suggest a biphasic regulation of the 5-HT1A receptor by the CB1 receptor, which appears to be responsible for the paradoxical effects of cannabinoids on mood and anxiety.

Also, some more stuff I haven't put in yet:

* The anxiolytic-like effects of low doses of CB1 receptor agonists are reversed by mu- and delta-opioid receptor antagonists, but not by kappa-opioid receptor antagonists.
* On the other hand, the anxiogenic-like effects of high doses of CB1 receptor agonists are antagonized by kappa-opioid receptor antagonists, but not by mu- or delta-opioid receptor antagonists.
* Thus, the biphasic, anxiolytic-like and anxiogenic-like effects of CB1 receptor agonists appear to be mediated by distinct mechanisms.

See these articles as well:

• Study Says Marijuana Has Antidepressant Effect, but Only at Low Doses
• Synthetic Form of THC is an Effective Anti-depressant at Low Doses
• Pot's Antidepressant Effects Reverse at High Doses
• Cannabis: Potent Anti-depressant in Low Doses, Worsens Depression at High Doses

And this quote from one of them:

From Dr. Gabriella Gobbi of McGill University (one of the scientists of the study): "Low doses had a potent anti-depressant effect, but when we increased the dose, the serotonin in the rats' brains actually dropped below the level of those in the control group. So we actually demonstrated a double effect: At low doses it increases serotonin, but at higher doses the effect is devastating, completely reversed."

In conclusion, the effects of CB1 receptor agonism [THC, the active constituent of marijuana, is a CB1 receptor agonist] on mood and anxiety are biphasic and dose-dependent, with low doses of CB1 receptor agonists producing antidepressant and anxiolytic effects, and high doses paradoxically resulting in the opposite, depressive and anxiogenic symptoms. These actions appear to be mediated by several different receptors, including positive effects at low doses via facilitation of 5-HT1A, mu-opioid, and delta-opioid activity, and negative effects at high doses via saturation of 5-HT1A activity and enhancement of kappa-opioid activity.

Cannabidiol (CBD) [another constituent of marijuana with an unknown mechanism of action] also has antidepressant and anxiolytic effects, inhibiting THC-induced depressive, anxiogenic, and psychotic effects, and enhancing 5-HT1A-mediated transmission. See this:

• Intravenous THC and Cannabidiol Experiment: From the Documentary "Should I Smoke Dope?"

With just THC the subject freaks out and has a panic attack, whereas combined administration of THC and CBD she appears to enjoy it very much and can't stop laughing at everything. A proper THC / CBD ratio and balance is very important in regards to marijuana and its effects on mood.

What else.. CB1 receptor agonists as well as CBD promote neurogenesis, notably in the hippocampus (probably through activation of 5-HT1A actually as they do the same). All of the currently known antidepressants do that (SSRIs, SNRIs, TCAs, MAOIs, etc), and it's now a defacto marker for determining if a purported antidepressant will be effective or not. In one study I saw rodents treated chronically with a CB1 receptor agonist were more immobile in the forced swim test (an indication of depression), yet in another I read that rodents exposed to chronic stress which subsequently developed depression had their symptoms reversed by chronic treatment of a CB1 receptor agonist. The conflicting results are probably just more dose-related discrepancies (the whole low dose = happy, high dose = panic thing).

Oh yeah, concomitant stress can lower the dose threshold for THC's effects becoming negative. This encompasses set and setting and mental state. If you're in a stressful situation (like work or socializing (and you're anxious about it)), you probably shouldn't smoke. If you're depressed or have severe anxiety / panic problems, you probably shouldn't smoke either.

Over time tolerance may develop to the negative effects (e.g., anxiety) as well.

Summary:

* Low doses of THC produce antidepressant and anxiolytic effects, whereas high doses produce the opposite, depressive and anxiogenic symptoms. Concomitant stress can turn a positive, low dose of THC into a negative experience.
* CBD antagonizes the depressive, anxiogenic, and psychotic effects of THC. Therefore, a proper THC:CBD ratio/balance is partially necessary for positive effects (low doses of THC are still antidepressant, but the depressive threshold is heightened with the more CBD present; hence, more enjoyable highs).
* THC and CBD promote neurogenesis (neuron/brain cell growth) in various areas of the brain, notably in the hippocampus. This has been shown to be a crucial action in the mechanisms of most, if not all antidepressants. Long-term benefits on mood and anxiety may become apparent from such an action.

[Thomas Paine]

^ nice research. I remember reading about the intravenous experiment. Also know someone personally who started hallucinating from the synthetic THC pill which doesn't have CBD in it. His doctor didn't even warn him and I don't think he had any idea of what to expect. Also I smoked many, many different strains at dispensaries in California and noticed the same pattern - the more CBD the more relaxing the strain was. I looked each one up online to find the ratios and see how much of a difference it made.

[crayzyMed]

I could order one of the JWH's to try this, what dose am i looking at for the antidepressant effect?
I could also try MJ offcourse but i dont remember it ever giving me a good effect. How much do you need to smoke? just one hit?

[N3XT2NON3]

Well I'm about to light one later tonight. I'll share my experience tomorrow

[pokeherpro]

I wanna grow and sell. Seems like easy money.

[meyaj]

Originally Posted by kos

After 2 years of trying to find a dealer I was blessed when I was driving a co-worker of mine to work and somehow he brought up the subject and eventually told me he deals so i could get some anytime I wanted. It is going to be amazing to finally have something to take the edge off. I'm still too young to drink and have been popping pills for a few months but they only cause me delirium and aren't the healthy choice for me. I was just wondering what everyones experience with marijuana was like. Did you have a panic attack or was it the time of your life? From what I remember I was calm and cool and I very much enjoyed this state of mind. So tell me about it.

Since you live in Canada, you should probably know that you can buy the highest grade weed online, delivered to your door. Unbelievably discreet.

[Medline]

Originally Posted by meyaj

Since you live in Canada, you should probably know that you can buy the highest grade weed online, delivered to your door. Unbelievably discreet.

OK, Canada I'm coming.

[pokeherpro]

Originally Posted by meyaj

Since you live in Canada, you should probably know that you can buy the highest grade weed online, delivered to your door. Unbelievably discreet.

Are you saying it's legal to buy weed online in Canada? Cause...it isn't.