Long term side effects of antipsychotics?

[MavenMI6Agent009]

Can atypical and typical anytipsychotics cause Tardive dyskinesia in long term or high dose treatments. ?

[crayzyMed]

Originally Posted by MavenMI6Agent009

Can atypical and typical anytipsychotics cause Tardive dyskinesia in long term or high dose treatments. ?

Yes, however in a rat study memantine seemed to reduce that risk.

Memantine attenuates the increase in striatal preproenkephalin mRNA expression and development of haloperidol-induced persistent oral dyskinesias in rats

Ole A. Andreassena, , , Jo Waageb, Bente Finsenc and Hugo A. Jørgensenb
a The Research Section, Department of Psychiatry, University of Oslo and Ullevål University Hospital, Kirkeveien 166, 0407, Oslo, Norway
b Department of Psychiatry and Locus on Neuroscience, University of Bergen and Bergen Psychiatric University Hospital, Bergen, Norway
c Department of Anatomy and Neurobiology, Institute of Medical Biology, University of Southern Denmark, Odense, Denmark
Accepted 16 September 2003. ; Available online 6 November 2003.
Abstract
Tardive dyskinesia (TD) is a serious motor side effect of long-term neuroleptic treatment that may persist after drug withdrawal. Alterations in striatal enkephalinergic neurons due to excessive glutamatergic activity is a possible pathogenetic mechanism. We studied the effect of the NMDA antagonist memantine in a rat model of TD, in which vacuous chewing movements (VCM) were induced by 20 weeks of haloperidol administration. The striatal density of preproenkephalin mRNA was measured and the number of neurons estimated. Haloperidol induced persistent VCM that was associated with increased striatal expression of preproenkephalin mRNA. Memantine inhibited the development of haloperidol-induced persistent VCM and attenuated the increase in preproenkephalin mRNA expression. This suggests that glutamate-mediated up-regulation of striatal enkephalin plays a role in the development of haloperidol-induced persistent oral dyskinesias.

[nothing to fear]

atypical antipsychotics are supposed to have a lower likelihood of causing TD. typical antipsychotics aren't even given out as often since atypical/second generation antipsychotics were developed.
however even with the first generation antipsychotics, it could take decades for symptoms of TD to show up. atypical antipsychotics haven't been around for anywhere near as long as typical antipsychotic so it's hard to determine their long-term side-effects.


i did a lot of reading on this a while back and the possibility of side-effects (not to mention it's effect on dopamine) seem too great for me to risk and it really encouraged me to go off any antipsychotics and i'm glad i did.

[arth98]

the atypical ones are safer but I would try benzos and antidepressants first as the atypicals are all heavy duty meds

[MavenMI6Agent009]

Originally Posted by arth98

the atypical ones are safer but I would try benzos and antidepressants first as the atypicals are all heavy duty meds

Well i take a typical antipsychotic Prolixin for hallucinations and racing thoughts. So what other med would help with racing thoughts besides a typical antipsychotic.?

[Upekkha]

The antipsychotics are the only class of medication that are targeted at hallucinations. Racing thoughts might be treated with a number of different medication types. Do you hear voices and does Prolixin help with you that?

I have schizophrenic symptoms that don't respond to any antipsychotic treatment. I was started on Zyprexa, and ran the gamut through all the atypical antispychotics to olders ones such as Navane and Haldol, finally I was just left on Clozaril until the symptoms became manageable on their own. None of the antipsychotics had any effect on my hallucinations, and I was able to get better without medication, which makes my case very atypical.

The reason I mention my history is because I am assuming you are having trouble finding relief from the schizophrenic symptoms, since I assume you have been on several different antipsychotics prior to Prolixin, right? They didn't just start you on Prolixin at the onset of symptoms did they?

[MavenMI6Agent009]

Originally Posted by Upekkha

The antipsychotics are the only class of medication that are targeted at hallucinations. Racing thoughts might be treated with a number of different medication types. Do you hear voices and does Prolixin help with you that? I assume you have been on several different antipsychotics prior to Prolixin, right? They didn't just start you on Prolixin at the onset of symptoms did they?

Prolixin helps me with the racing thoughts but not so much with hallucinations. Risperdal helped me quite a bit with hallucination but i stopped since i gained a lot of weight on it. I started with risperdal and tried many others. risperdal gave me the most help.

[Arisa1536]

Originally Posted by arth98

the atypical ones are safer but I would try benzos and antidepressants first as the atypicals are all heavy duty meds

I could not agree more
however, damn doctors are so ANTI benzo prescribing that its harder to obtain them but i would go with anti depressants, such as an SNRI like Effexor or a SSRI like fluoxetine cuz a lot of people find them useful, i am on effexor and its good and had been on two different types of antipsychotics, i was on a medium level dose of 100Mg of Quetiapine which gave me hunger pains, weight gain, sleep paralysis where i could not wake up and hallucinations
the docs lie when they say these sort of drugs are safe and yes they can cause TD when taken in large doses and the other drug i was given was Haldol and it was awful, i felt like my skin was crawling, i could not sleep and again i was starving....

because the doctors say they are not addictive they seem more than happy to throw them at people with anxiety, when really a little Benzo does not hurt ur body like these awful AntiPsychotics do

Basically anything ending with a Zine or ine tend to be in the antipsychotic family so be careful as people can end up like zombies on them

i hate them and would not recommended to anyone
unless u want to gain weight and sleep until next christmas

[MavenMI6Agent009]

So do all antipsychotics cause diabetes?

[Medline]

Originally Posted by MavenMI6Agent009

So do all antipsychotics cause diabetes?

Long term use could cause diabetes, but not all atypical APs have the same tendency to cause weight gain and decreased insulin sensitivity:

Recently, metabolic concerns have been of grave concern to clinicians, patients and the FDA. In 2003, the Food and Drug Administration (FDA) required all manufacturers of atypical antipsychotics to change their labeling to include a warning about the risks of hyperglycemia and diabetes with atypical antipsychotics. It must also be pointed out that although all atypicals must carry the warning on their labeling, some evidence shows that atypicals are not equal in their effects on weight and insulin sensitivity.[15] The general consensus is that clozapine and olanzapine are associated with the greatest effects on weight gain and decreased insulin sensitivity, followed by risperidone and quetiapine.[15] Ziprasidone and aripiprazole are thought to have the smallest effects on weight and insulin resistance, but clinical experience with these newer agents is not as developed as that with the older agents.[15]

http://en.wikipedia.org/wiki/Atypica...tic#Metabolism

[Arisa1536]

Originally Posted by MavenMI6Agent009

Can atypical and typical anytipsychotics cause Tardive dyskinesia in long term or high dose treatments. ?

Oh hell yes

Heck long term side effects aside, the short term effects are awful
At least these disgusting dangerous hell pills are not addictive because they cause so many side effects its not worth it.

there is a reason they are called Antipsychotic unless you have psycosis or schizophrenia i do not think they are worth using.
I have been on and off Seroquel because the doctors have pushed them and pushed them, then they put me on haldol OMG what a disgusting awful mess i was.

I got tardive akathisia within the first day. My skin felt like it was crawling and i felt like i was coming off a potent drug, i was unable to sit still and i was stuttering, my hands and legs started jerking involuntary and i was going out of my mind.

Side effects in antipsychotics affect Two third of the people who take them
Thats ALOT considering the amount sold and taken and given to people around the world.

Originally Posted by http://en.wikipedia.org/wiki/Antipsychotic

A number of harmful and undesired (adverse) effects have been observed, including lowered life expectancy, weight gain, (hyperprolactinaemia), lowered white blood cell count (agranulocytosis), involuntary repetitive body movements (tardive dyskinesia), diabetes, an inability to sit still or remain motionless (tardive akathisia), sexual dysfunction, a return of psychosis requiring increasing the dosage due to cells producing more neurochemicals to compensate for the drugs (tardive psychosis), and a potential for permanent chemical dependence leading to psychosis much worse than before treatment began, if the drug dosage is ever lowered or stopped (tardive dysphrenia).

http://en.wikipedia.org/wiki/Antipsychotic

[crayzyMed]

My mum suffers from Tardive dyskinesia, she can barely talk right or act normal, at times she has to cry because of it. It looks like she has parkinson, she had it in the past too and took 3 years to go away, lets hope it doesnt take as long this time

[Arisa1536]

Originally Posted by crayzyMed

My mum suffers from Tardive dyskinesia, she can barely talk right or act normal, at times she has to cry because of it. It looks like she has parkinson, she had it in the past too and took 3 years to go away, lets hope it doesnt take as long this time

Crazymed i feel for you i really do
lots of hugs and virtual glomps coming your way
what i suffered was bad enough but Dyskinesia must be horrific

damn antipsychotic crap

[crayzyMed]

Thx

I hope i find a way to fix her back up.

[Arisa1536]

You will but it could take some time thats all

[MavenMI6Agent009]

Update: been on Prolixin for long term approx. 2 years daily and no serious side effects except for crawling on my skin sensation. I plan on getting off without any withdrawl.

[MavenMI6Agent009]

Bump once again. Going off the Prolixin(Fluphenazine) and tapering off from 7.5 to 5mg to 2.5mg than stop. I dont need it anymore since I can handle my thoughts when the race.