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Old 09-15-2010, 01:52 PM   #1 (permalink)
 
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Default Is it OK to break Wellbutrin SR tablets in half?

I want to retry Wellbutrin, but the dose of 150mg gave me anxiety.

My doctor said it was OK to break the Wellbutrin SR tablets in half, "it might release all at once, but that shouldn't be a problem"

But i am wondering if breaking the Wellbutrin SR tablets in half would screw up the sustained release effect? And what your experience(s) have been with breaking the SR tablet in half.


Thanks,
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Old 09-15-2010, 02:21 PM   #2 (permalink)
 
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Chances are it will break the slow-release. 75mg all at one time shouldn't be a problem though. You may have some GI problems the first couple times you take it.
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Old 09-15-2010, 02:54 PM   #3 (permalink)
 
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Originally Posted by rustybob View Post
Chances are it will break the slow-release. 75mg all at one time shouldn't be a problem though. You may have some GI problems the first couple times you take it.
But would 75mg all at once FEEL different? Would it cause a spike and a drop?

There must be a reason for the sustained release.
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Old 09-15-2010, 03:41 PM   #4 (permalink)
 
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Originally Posted by Eric69 View Post
But would 75mg all at once FEEL different? Would it cause a spike and a drop?

There must be a reason for the sustained release.


Cheers,
Yeah, so the drug company could have a new patent on it

But in all seriousness, most SR stuff is mainly for stopping GI problems, or in the case of Effexor, so that you only have to dose once a day.

For bupropion, since too much made you anxious, I'd probably only dose twice at the most per day, split about 8 hours apart.
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Old 09-15-2010, 03:49 PM   #5 (permalink)
 
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Wellbutrin: dose three times a day
Wellbutrin SR: dose twice a day
Wellbutrin XL: dose once a day

(meaning split the doses up)
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Old 09-15-2010, 04:47 PM   #6 (permalink)
 
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Quote:
Originally Posted by Dr House View Post
Wellbutrin: dose three times a day
Wellbutrin SR: dose twice a day
Wellbutrin XL: dose once a day

(meaning split the doses up)
What happens if you take Wellbutrin SR once per day? Cheers,
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Old 09-15-2010, 05:24 PM   #7 (permalink)
 
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Originally Posted by Eric69 View Post
What happens if you take Wellbutrin SR once per day? Cheers,
You'd just be extremely limited in efficacy. Bupropion's half life is about 10 hours. The SR pills spread that out to about 17 hours, but once a day won't keep a steady amount of bupropion in your system.
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Old 09-15-2010, 05:31 PM   #8 (permalink)
 
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Originally Posted by rustybob View Post
You'd just be extremely limited in efficacy. Bupropion's half life is about 10 hours. The SR pills spread that out to about 17 hours, but once a day won't keep a steady amount of bupropion in your system.
Wouldn't that be perfect?

Take it in the morning, and then by bedtime there is half the dose in your system.

And then take it in the morning again
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Old 09-15-2010, 05:33 PM   #9 (permalink)
 
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Originally Posted by rustybob View Post
You'd just be extremely limited in efficacy. Bupropion's half life is about 10 hours. The SR pills spread that out to about 17 hours, but once a day won't keep a steady amount of bupropion in your system.
So say you took 100mg SR once per day.

It would be like:

Day 1: 100mg
Day 2: 50mg (left over) + 100mg
Day 3: 25mg (left over) + 50mg (left over) + 100mg

AND SO ON...

Each day would accumulate more and more bupurion in your system...... although it could be a little slower i think.
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Old 09-15-2010, 11:26 PM   #10 (permalink)
 
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Had some wellbutrin SR lying in my bag. I cut in in 4 pieces and took one of them.
I ll see how it goes.
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Old 09-15-2010, 11:44 PM   #11 (permalink)
 
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Quote:
Originally Posted by Eric69 View Post
So say you took 100mg SR once per day.

It would be like:

Day 1: 100mg
Day 2: 50mg (left over) + 100mg
Day 3: 25mg (left over) + 50mg (left over) + 100mg

AND SO ON...

Each day would accumulate more and more bupurion in your system...... although it could be a little slower i think.



Cheers,
You got the basic idea but the numbers would be lower due to the slow release. Some would get released instantly and some of that would be gone earlier.

So it would build up pretty sloew for you. And I dunno about you, but I want results now
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Old 09-16-2010, 01:57 AM   #12 (permalink)
 
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Quote:
Originally Posted by Eric69 View Post
There must be a reason for the sustained release.
There is, but a finance major such as myself could likely explain it at least as well as any pharmacist, seeing how it has basically nothing to do with pharmacology.

GSK (big evil drug company) wanted to milk their cash cow for as long as possible, thus multiple reincarnations of Wellbutrin.

1. Wellbutrin: take every 8 hours

The patent is near expiration, so go to step 2:

2. Wellbutrin SR: take every 12 hours

Damn, that patent is near expiration again, so go to step 3:

3. Wellbutrin XL: take every 24 hours

Damn, we've run out of steps and the bottom line is sinking!!! Well, had a good run, staying under patent for 20+ years with this silly, though, quite common game where the FDA deems slapping on a time release coating to be a "new" drug.
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Old 09-16-2010, 07:33 AM   #13 (permalink)
 
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Quote:
Originally Posted by karoloydi View Post
Had some wellbutrin SR lying in my bag. I cut in in 4 pieces and took one of them.
I ll see how it goes.

How did cutting the SR work out for you?
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Old 09-16-2010, 07:35 AM   #14 (permalink)
 
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I took Wellbutrin XL 150mg daily with Celexa....too much anxiety.
Tried Wellbutrin SR 100 (generic) daily with Celexa...seemed even more anxiety
Back to Wellbutrin XL150mg with Celexa...trying 10g Celexa instead of 20mg.
Any suggestions appreciated.
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Old 09-16-2010, 09:18 AM   #15 (permalink)
 
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Quote:
Originally Posted by rustybob View Post
You got the basic idea but the numbers would be lower due to the slow release. Some would get released instantly and some of that would be gone earlier.

So it would build up pretty sloew for you. And I dunno about you, but I want results now
That's true.

The problem is, my body is pretty sensitive, so i'm willing to wait a little bit longer for results.

150mg was too much for me, so i am debating whether to try 100mg SR once per day or cut the 150mg pill into two pieces, 75mg per day. The doctor said it's OK to cut the SR pills in half, but hmmm.


Cheers,
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Old 09-16-2010, 09:19 AM   #16 (permalink)
 
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Quote:
Originally Posted by karoloydi View Post
Had some wellbutrin SR lying in my bag. I cut in in 4 pieces and took one of them.
I ll see how it goes.
Please let me know how this goes.


Cheers,
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Old 09-16-2010, 09:20 AM   #17 (permalink)
 
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Quote:
Originally Posted by KarenR View Post
I took Wellbutrin XL 150mg daily with Celexa....too much anxiety.
Tried Wellbutrin SR 100 (generic) daily with Celexa...seemed even more anxiety
Back to Wellbutrin XL150mg with Celexa...trying 10g Celexa instead of 20mg.
Any suggestions appreciated.
Yeah the 150mg gave me anxiety too.

My doctor prescribed me 100mg SR which is the lowest dose available. I am deciding wether to try that dose, or cut the 150mg pills in half and try 75mg per day.

It's cheaper for me to cut the 150mg pills in half because i already have them.


Cheers,
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Old 10-05-2010, 11:49 AM   #18 (permalink)
 
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Quote:
Originally Posted by Eric69 View Post
That's true.

The problem is, my body is pretty sensitive, so i'm willing to wait a little bit longer for results.

150mg was too much for me, so i am debating whether to try 100mg SR once per day or cut the 150mg pill into two pieces, 75mg per day. The doctor said it's OK to cut the SR pills in half, but hmmm.


Cheers,
I take 150 mg twice daily and it's causing me extreme headaches
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Old 10-05-2010, 02:15 PM   #19 (permalink)
 
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Quote:
Originally Posted by Eric69 View Post
Please let me know how this goes.


Cheers,
It was fine. The duration was almost the same, just slightly less.
The intensity was almost the same for the first hour or two and then it calmed down. But it felt more potent than 1/4 of the potency of the whole pill.
I also took it with some gabapentin. So maybe that altered my perception of the effects.
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Old 10-13-2010, 07:05 PM   #20 (permalink)
 
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Quote:
Originally Posted by Eric69 View Post
Yeah the 150mg gave me anxiety too.

My doctor prescribed me 100mg SR which is the lowest dose available. I am deciding wether to try that dose, or cut the 150mg pills in half and try 75mg per day.

It's cheaper for me to cut the 150mg pills in half because i already have them.


Cheers,
Are the 150mg the XL version or the SR version? Did you try cutting them in half? My pdoc said I can cut the XL in half??? I have the 150mg XL version and they're too stimulating so he said to cut them in half. Kind of scared to but the 100SR version are too strong also (as far as causing anxiety). He wants me to take Xanax with the Wellbutrin to cut down the anxiety. Anyone else using Xanax with Wellbutrin??
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