Has anyone tried a dopamine agonist?

[Diya]

For how long have you been on it? At what dose? Do you notice any improvement? Any nasty side effects you'd like to share? Any other drug in your regimen? (i.e. SSRI)

[Jrock]

I have wondered the same thing.

[rocknroll714]

Euphoria had some pramipexole and a bunch of other stuff coming I believe but his parents caught him. I'm curious about this as well..

[jjyiss]

does aniracetam count?

""This shows that aniracetam's anxiolytic mechanism is facilitated by D2/D3 dopamine, nicotinic acetylcholine, and 5-HT2A receptors""

if so then, it lasts 4-5 hours for me, and it works wonderfully at 500mg.

[miko]

Hey guys! I'm tried Ropinirole ( because it's cheaper... ), and... wow, it's great, you know, I tried SSRI ( not tolerate it! ), tricylic, mianserin, and many other antidepressants, and I must say that combo of wellbutrin (150 mg), ropinirole and oxybutynin (anticholinergic drug, that slows my heart, stop sweating and make me more calm..., not sure how it's working, but I think it's because M3 acetylcholine antagonism), it's the best social anxiety combo for me !!! Sorry for my english, i'm from Poland but I want to share it with you. Maybe someone can use it Pozdro from Poland

[rocknroll714]

Originally Posted by miko

Hey guys! I'm tried Ropinirole ( because it's cheaper... ), and... wow, it's great, you know, I tried SSRI ( not tolerate it! ), tricylic, mianserin, and many other antidepressants, and I must say that combo of wellbutrin (150 mg), ropinirole and oxybutynin (anticholinergic drug, that slows my heart, stop sweating and make me more calm..., not sure how it's working, but I think it's because M3 acetylcholine antagonism), it's the best social anxiety combo for me !!! Sorry for my english, i'm from Poland :D but I want to share it with you. Maybe someone can use it :) Pozdro from Poland :)

Nice! Thanks for the report :)

[euphoria]

Originally Posted by miko

Hey guys! I'm tried Ropinirole ( because it's cheaper... ), and... wow, it's great, you know, I tried SSRI ( not tolerate it! ), tricylic, mianserin, and many other antidepressants, and I must say that combo of wellbutrin (150 mg), ropinirole and oxybutynin (anticholinergic drug, that slows my heart, stop sweating and make me more calm..., not sure how it's working, but I think it's because M3 acetylcholine antagonism), it's the best social anxiety combo for me !!! Sorry for my english, i'm from Poland but I want to share it with you. Maybe someone can use it Pozdro from Poland

Just take carvedilol or clonidine if you want to lower effects of adrenaline/noradrenaline (anxiety, fast heartbeat, etc.). Benzos would also help this, and so would magnesium glycinate. SSRIs would reduce anxiety if you titrate your dose up very slowly so it is tolerable, and they could be taken with mirtazapine for less side-effects and better response.

Oxybutynin taken with Wellbutrin and ropinirole is just a recipe for psychosis (particularly of the paranoid type) due to oxybutynin blocking cholinergic receptors in the brain. Taking these drugs together will make you crazy and stupid, it's just a matter of time.

[miko]

Clonidine make me feel like **** beta adrenolitics is good, but for me (I have something like Raynaud's symptome), they make me cold. Carvedilol is also alfa blocker, but I prefer Nebivolol+Alfa Blocker. Benzos is also good but I don't want to take it. Believe me, even Benzos don't make me feel soo good as dopamine agonists! I don't know how to explain this in english, but this meds take back my laught, my humour, make me calm. I don't know, but maybe I have restless legs because this meds make me so patient. I never know that I can be so patient!!!

I know that anticholinergics are bad. They can take you memory. There is study that say Oxybutynin decrease memory, and I want change it to glycopyrrolate (avert),that don't cross blood/brain barrier.

SSRI make me Akathisia, Restless Legs, and Anxiety I have never been :f That's I search net for other meds that make me cure from social anxiety. And I found it. For me it's easy choice -anxiety or danger with my meds. You know what I've chosen...

I have no schizo episodes, so maybe I'm in this good situation that I can take meds working on dopamine. In my life, Parkinsons disease is more possible

[Beffrey28]

Originally Posted by miko

I know that anticholinergics are bad. They can take you memory. There is study that say Oxybutynin decrease memory, and I want change it to glycopyrrolate (avert),that don't cross blood/brain barrier.

Won't nootropics and supps like Piracetam, Choline, Huperzine A and Acetyl L-Carnitine help against the cognitive decline?

[miko]

Don't know, but anticholinergics block acetylcholine receptors, and Choline, ACL increase acetylcholine levels. Maybe Nootropics may help if they working on other rules, like piracetam? Oxybutynin is bad becauce it's blocking three M receptors, but it's cheap and available ( Ditropan ). Tricylic blocking mainly M1 receptors in brain, that's they can do excessive sweating, and all M3 blocking Oxybutynin is used in excessive sweating treatment. In Parkinsons, there is no dopamine, and too much acetylcholine, and that's why we have excessive sweating, seborrhea, drooling. M3 acetylcholine receptors respond for glands secretion. There is study on net that's say too much acetylcholine is one of the reasons of depression. Anticholinergics working on me, increase my mood, I think it's because, they somehow increase dopamine.

[Beffrey28]

Originally Posted by miko

Don't know, but anticholinergics block acetylcholine receptors, and Choline, ACL increase acetylcholine levels. Maybe Nootropics may help if they working on other rules, like piracetam? Oxybutynin is bad becauce it's blocking three M receptors, but it's cheap and available ( Ditropan ). Tricylic blocking mainly M1 receptors in brain, that's they can do excessive sweating, and all M3 blocking Oxybutynin is used in excessive sweating treatment. In Parkinsons, there is no dopamine, and too much acetylcholine, and that's why we have excessive sweating, seborrhea, drooling. M3 acetylcholine receptors respond for glands secretion. There is study on net that's say too much acetylcholine is one of the reasons of depression. Anticholinergics working on me, increase my mood, I think it's because, they somehow increase dopamine.

Ok thanks for the info. Reason i ask is because i want to try Oxy for facial blushing. On some blushingforums they say it helps a lot.
But my memory is pretty strong and i really don't want to mess a lot with my shortterm memory. I have Piracetam, Choline and ALCAR at home.
Maybe one of the Med experts can explain if supps and nootropics help when taking Oxybutynin?

[rocknroll714]

Originally Posted by miko

Don't know, but anticholinergics block acetylcholine receptors, and Choline, ACL increase acetylcholine levels. Maybe Nootropics may help if they working on other rules, like piracetam? Oxybutynin is bad becauce it's blocking three M receptors, but it's cheap and available ( Ditropan ). Tricylic blocking mainly M1 receptors in brain, that's they can do excessive sweating, and all M3 blocking Oxybutynin is used in excessive sweating treatment. In Parkinsons, there is no dopamine, and too much acetylcholine, and that's why we have excessive sweating, seborrhea, drooling. M3 acetylcholine receptors respond for glands secretion. There is study on net that's say too much acetylcholine is one of the reasons of depression. Anticholinergics working on me, increase my mood, I think it's because, they somehow increase dopamine.

Indeed they do. Pro-muscarinics inhibit DA release in certain areas and are pro-depressive.

Nice pharmacology tidbits btw.

[Diya]

Neurotransmitters work in a cycle. If a drug works for one then one should feel really lucky to have finally achieved a proper neurotransmitter balance. If it did affect your memory and stuff maybe lower the dose?

I have to agree through, dopaminergic + anticholinergic could be rather problematic.

[miko]

Facial blushing? So you are getting red in some situtations? Hmm, oxy stops sweating, so you can get red from getting up your temperature You know, I'm always white as a sheet I want to be red, but my blood cyrculation is bad. If you want to try Oxy, better is Avert! http://www.pharmacy.ca/cgi-bin/Pharm...!&GETSPECIALS= you can buy it here

[Beffrey28]

Originally Posted by miko

Facial blushing? So you are getting red in some situtations? Hmm, oxy stops sweating, so you can get red from getting up your temperature You know, I'm always white as a sheet I want to be red, but my blood cyrculation is bad. If you want to try Oxy, better is Avert! http://www.pharmacy.ca/cgi-bin/Pharm...!&GETSPECIALS= you can buy it here

Yes my head turns bright red in the most 'normal' situations like somebody asking a question. The problem is not the blushing, but the fear of it.
I've always blushed, but only since my 19th i developed a phobia for it.
That phobia turned into a social phobia. Before i had no trouble in social situations, because the blushing wasn't a big issue.
It became a huge issue after someone commented about it in a very harsh way. I started avoiding things and it got worse and worse, eventually becoming a social phobia.
If i can find something that prevents me from getting red, i know i can turn the SA around.
I've read the Oxy works very well for a lot of blushers. Only problem is the side effects. But if they are not too bad i will trade my blushing for it anyday.
Maybe the memory problems with Oxy will turn out positive. Maybe they will make me forget about blushing episodes from the past lol.
Thanks for the info!

[rocknroll714]

Originally Posted by Beffrey28

Yes my head turns bright red in the most 'normal' situations like somebody asking a question. The problem is not the blushing, but the fear of it.
I've always blushed, but only since my 19th i developed a phobia for it.
That phobia turned into a social phobia. Before i had no trouble in social situations, because the blushing wasn't a big issue.
It became a huge issue after someone commented about it in a very harsh way. I started avoiding things and it got worse and worse, eventually becoming a social phobia.
If i can find something that prevents me from getting red, i know i can turn the SA around.
I've read the Oxy works very well for a lot of blushers. Only problem is the side effects. But if they are not too bad i will trade my blushing for it anyday.
Maybe the memory problems with Oxy will turn out positive. Maybe they will make me forget about blushing episodes from the past lol.
Thanks for the info!

Weird how so many people have facial blushing with SA and are so insecure about it.. I either don't have it or never noticed, though I seriously doubt I don't have it as I'm pretty pale, but I still find it odd. Even the idea of it doesn't seem all that anxiety-provoking to me.. the idea of flushing and/or shaking is actually somewhat relieving as then people notice I'm anxious and I feel like I have an excuse and I become more relaxed. That's just me though.

By the way, beta blockers could probably nullify facial flushing, so if it's that bad for a problem for you, even if they're not the greatest of meds of all time for SA (though I do think they hold promise; however, nobody else around here really seems to think so), they could be worth looking into nonetheless for your case. Not to mention they alleviate a lot of the other noticeable peripheral effects of anxiety like muscle tension, trembling and/or full-blown shaking, nausea or the "my stomach just fell in on itself" sensation, and so forth.

[Beggiatoa]

Pramipexole is great stuff and probably deserves its own thread. Best dopaminergic I've come across.

[Jrock]

How is a Dopamine Agonist suppose to improve SA?

[rocknroll714]

Originally Posted by Beggiatoa

Pramipexole is great stuff and probably deserves its own thread. Best dopaminergic I've come across.

How was it?? I'd like your full experience if you don't mind :)

[miko]

Yeah, dopamine agonists it's best med for social anxiety, for me