Ethylphenidate

[jonny neurotic]

So I got some EPD a few weeks ago and have been taking it every day. I have pretty bad ADHD and have had no diagnosis as of yet and have never tried any of the official meds for it. I mixed the pure powder with ground sugar to make it easier to measure out a dose and have been taking roughly 5 mg per dose. It lasts roughly 2 hours and at this dose there were no after effects and no side effects to speak of.

It has worked wonders for my ADHD. I have been super productive for the last couple of weeks and it seems the longer I take it the more focused and motivated I become. My thinking is clearer and I find myself becoming preoccupied with things I realy should be doing when I am procrastinating - so I procrastinate less. It is wonderful and the effectiveness of it has made me even more certain that I have ADHD. No tolerance has developed at this dose and no insomnia. Even my SA has began to come into line, possibly owing to the clearheadedness that I now enjoy.

I ran out a couple of days ago and am missing it dearly. I did not feel the need to(nor did I) drink any coffee while using EPD. Caffeine is a liar anyway. It promises so much but lets me down when I need it most. I wonder if the caffeine has effected my anxiety too. Perhaps not having any caffein in my system is the reason my SA has diminished. IDK. I have placed another order for this wonderful chemical and hope to be as productive for the rest of the year, if not more so...

[GotAnxiety]

Wow, you can buy 1kg bag for 5,250 dollar's! lol how much did you pay for your's?

[jonny neurotic]

I don't want to break the rules so let's just say I ordered less that 1kg and paid less than 5 grand...

[jonny neurotic]

I should also point out that I had been placing the doses between my lower lip and gum and allowing it to absorb that way. It doesn't work when swallowed and the nasal membranes don't take too kindly to it...

[swim]

Is it a stimulant like Ritalin? What's its commercial name?

[Duke of Prunes]

I was under the impression that it was just a more euphoric version of methylphenidate. Never tried it myself, unless drinking lots of alcohol with lots of Ritalin actually produces enough of it to have any effect.

[Legionnaire]

I looked at some reviews and it looks like most people like it for it's euphoric effect and not for it's ability to enhance cognitive energy or function, but I'll still probably try it eventually to see for myself.

[jonny neurotic]

Originally Posted by Legionnaire

I looked at some reviews and it looks like most people like it for it's euphoric effect and not for it's ability to enhance cognitive energy or function, but I'll still probably try it eventually to see for myself.

Can't compare it to anything because it is the first time I have used a stimulant for this. Most of the reviews on bluelight that i read said that it wasn't much of a party drug unless combined with other stuff. All the people who had taken enough of it to achieve any appreciable euphoria mentioned heavy come down the next day. It seams that dopamine increase alone is not sufficient to produce euphoria and that the only way one can get high off this stuff is to take so much that the noradrenaline reuptake inhibition becomes apparent. At these dosages the dopamine increase would be huge causing lots of receptor downregulation.

The dosage I have been working with has been roughly 5mg. At 10 mg it became counterproductive and I got SFA done. 10 mg also caused me to experience ever so slight withdrawl effects next day. 5mg was perfect with no real stimulation other than the fact that I had no desire to imbibe massive quantities of coffee like i usually do. Perhaps methylphenidate is better because of the noradrenergic effects but this is what contributes to the side effects too. I fancy putting some clonidine or guanfacine into the mix to catch the alpha receptors in the frontal lobes just to see if it works any better.

Be careful with this stuff. I have seen lots of comments on the after effects being worse than cocaine or meth...

[Duke of Prunes]

I was under the impression that ethylphenidate would be superior to methylphenidate (which I actually find quite euphoric and free of side-effects/crashes at 10-15 mg buccally even after being on 60 mg a day for months) in every way, like d-amphetamine versus l-amphetamine. Maybe the manufacturer used a crappy synth and you've got erythro-ethylphenidate rather than threo-ethylphenidate?

[jonny neurotic]

Originally Posted by Duke of Prunes

I was under the impression that ethylphenidate would be superior to methylphenidate (which I actually find quite euphoric and free of side-effects/crashes at 10-15 mg buccally even after being on 60 mg a day for months) in every way, like d-amphetamine versus l-amphetamine. Maybe the manufacturer used a crappy synth and you've got erythro-ethylphenidate rather than threo-ethylphenidate?

What gives you this impression? The stuff worked wonders with hardly any side effects. The 10mg dose became counterproductive because it was too 'satisfying'. I imagine if I increased the dose further this satisfied feeling would turn into euphoria. I had no intention of testing this hypothesis because I did not want to develope any tolerance. There was some slight withdrawl the next day when I used the 10mg but the 5mg was still as effective and I felt no withdrawl when it ran out(other than the fact that I am back to normal, which sucks). One other effect of consequence was that I had absolutely no desire to get high in any way shape or form. Normally I have a constant urge to get high on something. Not so while on this even though I wasn't 'buzzing'. Increased impulse control I would guess, owing to the efficacy of this substance in combating my ADHD.

It has less noradrenergic effects than methylphenidate which would make it less stimulating and possibly less euphoric. Depends on the individuals brain chemistry I guess. It is noteworthy that euphoriants like cocaine and meth also increase serotonin as well as dopamine and noradrenaline.

In anycase both isomers have similar pharmacological profiles, unlike methylphenidate where the l-isomer is more noradrenergic. Also your presuposition is flawed because noradrenaline may play a role in ADHD so methylphenidate may be superior as a monotherapy. I wish to test this hypothesis by trialing the ethylphenidate with an alpha agonist like clonidine...

[Duke of Prunes]

I probably should have read your post a bit more carefully, I assumed you were interested in the euphoric/anxiolytic/pro-social effects as well.

[euphoria]

I've been using 10mg + 5mg + 5mg a day of ethylphenidate, to get the ball rolling until I get my script for methylphenidate. Reasons for taking it are anhedonia, apathy, and a total lack of motivation or ability to focus. The other meds I'm on are:

20mg fluoxetine (depression/anxiety)
10mg clobazam (seizures)
0.6mg buprenorphine (opioid dependency)

For me at least, the initial effects of stimulants (reuptake inhibitors more so than amphetamine-like catecholamine releasers) are very different to those felt on subsequent days of usage. The mild euphoria / anhedonia relief is strongest with the first dose, followed by a crash, then a return of desirable effects when you redose, lessening each time but with the general feeling of stimulation from dosing still as strong as ever. At about 4 days in on my ethylphenidate regimen, I get no real mood lift, anhedonia relief or euphoria from dosing, just mild stimulation and disappearance of the fatigue I feel at night / in the morning without any ethylphenidate active (indicating a developing physical dependency). But at least the crashes have gone.

My guess for why this happens is, you need to take a stimulant for the several weeks it takes for feedback loop inhibition (dopamine autoreceptors reducing synthesis & release, etc.) to stop, before the stim becomes fully effective and more like it felt with the first dose, except consistently over the course of the day rather than with ups and downs. The mood effects should return.

Ethylphenidate actually makes me feel pretty agitated and unhappy now even at this 10mg dose, but I just need to get through it for the results. Experimenting with it before this, 20mg or more seemed to be needed to treat my anhedonia/ADD, but I can't tolerate the adjustment period to that kind of dose. Will need to ramp up slowly.

Could be wrong, but it seems to be how things work. Feel like **** for 2 weeks, then the meds work.

I have gone on ethylphenidate binges a few times by the way, as I have with other stimulants. The first dose is always the best, then if you keep redosing to chase the euphoria, you get more and more agitated to the point you can't tolerate any more, then you have a crash that makes you wish you were never born.

The only way to use stimulants therapeutically (other than prn use which I don't believe in for most people) is to aim for consistent blood levels throughout the day and to expect results only after a few bad weeks - with ethylphenidate, this means if you start the day with 10mg, use 5mg doses every 5 or so hours afterwards, seeing as ethylphenidate levels drop by half every 3-6 hours. My guess based on personal experience, don't know the actual half life. But don't judge how much stimulant is in your body based on how euphoric it is making you feel, judge it by your heart rate, appetite, and other stimulant effects not related to mood. If you start crashing before it's time to redose, just power through it.

[jonny neurotic]

Originally Posted by euphoria

if you start the day with 10mg, use 5mg doses every 5 or so hours afterwards, seeing as ethylphenidate levels drop by half every 3-6 hours. My guess based on personal experience, don't know the actual half life. But don't judge how much stimulant is in your body based on how euphoric it is making you feel, judge it by your heart rate, appetite, and other stimulant effects not related to mood. If you start crashing before it's time to redose, just power through it.

I got on much better taking 4 x 5mg doses spaced at least 2 and a half hours apart. I avoided the higher dose because of it being counterproductive and leaving me feeling withdrawal effects the next day. I imagine tolerance would have set in pretty quickly had I continued at this dose and the desired effects may have returned once it became less satisfying.

I have done other posts on why I think the initial euphoria from higher doses of stims is not where the most benefit comes from. It may help with SA in the now but those immediate effects are short lived and undesirable after effects usually follow. I personally think that long term, every day low doses along with CBT would be the most effective approach, wit maybe some benzos or something to kill the SA when absolutely necessary. My hypothesis is that the consistently but mildly elevated dopamine levels will change the way our brains process emotional stimuli and will aid in the eventual recovery from this condition rather than this quick fix, short lived euphoria business followed by withdrawal effects...

[norad]

Is Ethylphenidate even used to treat ADD?
From what I read when you take MPH and drink alcohol you get Ethylphenidate which acts different than MPH that's why people mustn't drink alc when on MPH. But if Ethylphenidate is actually good then this would mean that drinking alc when on MPH would also be good.

[Duke of Prunes]

Originally Posted by jonny neurotic

I got on much better taking 4 x 5mg doses spaced at least 2 and a half hours apart. I avoided the higher dose because of it being counterproductive and leaving me feeling withdrawal effects the next day. I imagine tolerance would have set in pretty quickly had I continued at this dose and the desired effects may have returned once it became less satisfying.

I have done other posts on why I think the initial euphoria from higher doses of stims is not where the most benefit comes from. It may help with SA in the now but those immediate effects are short lived and undesirable after effects usually follow. I personally think that long term, every day low doses along with CBT would be the most effective approach, wit maybe some benzos or something to kill the SA when absolutely necessary. My hypothesis is that the consistently but mildly elevated dopamine levels will change the way our brains process emotional stimuli and will aid in the eventual recovery from this condition rather than this quick fix, short lived euphoria business followed by withdrawal effects...

I'm considering giving this a try with MPH. Atm I'm taking 20 mg three times per day (usually 15 mg four times but my sleep is back to front and I'm trying to fix it, so having to take a fourth dose at midnight or something would kinda suck), but I'm considering taking a two week break or so and then starting again with 10 mg every two hours or 5 mg an hour instead. Does that sound any good to you?

I'm actually finding that 20 mg of MPH is too much for daily use, as I just end up spaced out and content with doing nothing all day, but I was quite happy on 10 mg until I built up a bit of tolerance to the euphoria and thought it had pooped out, then had my dose upped.

[norad]

Do you guys even know what you are doing? Mixing MPH with EPH? Sounds like some dangerous experiments going on here. I don't know if I can endorse that.

[jonny neurotic]

Originally Posted by Duke of Prunes

I'm considering giving this a try with MPH. Atm I'm taking 20 mg three times per day (usually 15 mg four times but my sleep is back to front and I'm trying to fix it, so having to take a fourth dose at midnight or something would kinda suck), but I'm considering taking a two week break or so and then starting again with 10 mg every two hours or 5 mg an hour instead. Does that sound any good to you?

I'm actually finding that 20 mg of MPH is too much for daily use, as I just end up spaced out and content with doing nothing all day, but I was quite happy on 10 mg until I built up a bit of tolerance to the euphoria and thought it had pooped out, then had my dose upped.

I can't say. I haven't experienced methylphenidate. I think if I could I would much prefer a timed release format. If it is a high enough quality product so as to ensure consistent plasma levels of the drug I think this would be the best bet. With mehtylphenidate I would definitely use an alpha agonist like clonidine or guanfacine to mitigate the adrenergic effects.

Bear in mind that I am not swallowing the ethyl because it is around 8 times less potent that way. I don't know about the bioavailability of methyl. I dare say that taking lower doses more frequently would be preferential but I don't know about the spacing of the doses. You can but try. Do keep me posted...

Originally Posted by norad

Do you guys even know what you are doing? Mixing MPH with EPH? Sounds like some dangerous experiments going on here. I don't know if I can endorse that.

Who said anything about mixing the two? And why would that be any more dangerous than taking a higher dose of either?

Is Ethylphenidate even used to treat ADD?
From what I read when you take MPH and drink alcohol you get Ethylphenidate which acts different than MPH that's why people mustn't drink alc when on MPH. But if Ethylphenidate is actually good then this would mean that drinking alc when on MPH would also be good.

Don't fancy the idea of drinking throughout the day. In fact, I don't like alcohol too much at all. TBH I don't think that it would cause any great quantity of ethylphenidate to be generated...

[norad]

As far as I know EPH acts different than MPH which is why you cannot predict the effects of drinking alcohol when you take MPH. That's at least what I read.