Effexor XR 300mg poop out....

[gillettecavalcad3]

Is that possible? I might just be imagining it. If it has, .....then that is a major setback.

[jim_morrison]

What are the signs and symptoms that your experiencing?
Have you ever thought of using effexor just prn as you would klonopin? since you said that it helped you immediately?

[gillettecavalcad3]

RLS has kicked back in, .....Still got the concentration and ability to remember vast amounts of information. My brother noticed that I was acting the way I used to, .....being paranoid with my mates and touchy.

I went out and had quite a few drinks last week because it was my cousins birthday. I'm hoping that it has something to do with that.

[RockiNToM]

It could well be that. Certainly I have and also read from others, about anti-depressants working less efficiently when combined with alcohol the days after. It will revert back to normal (if it is the alcohol at fault) but it may take a week or 2 until maximum effect is felt again. It's weird I know - I experienced this problem a lot with Effexor too.

[jim_morrison]

Originally Posted by gillettecavalcad3

RLS has kicked back in, .....Still got the concentration and ability to remember vast amounts of information. My brother noticed that I was acting the way I used to, .....being paranoid with my mates and touchy.

I went out and had quite a few drinks last week because it was my cousins birthday. I'm hoping that it has something to do with that.

I think effexor may be able to cause RLS through increasing noradrenaline, I'm not sure.

But yeah it may be just the booz, so give it a few days and update us on how you feel.

[RockiNToM]

I get RLS with SSRIs lol so I doubt it's just the noradrenaline. I got it especially bad with Zoloft and Paxil.

[when will we be new skin]

Yeah I'm pretty sure my Effexor at 300 mgs stopped working.

[jim_morrison]

Howcome everyone seems to be taking 300 mg? I thought the FDA max was 225

[when will we be new skin]

I guess that's their recommendation? I don't think it's against the law to increase the dosage. Who knows.

[RockiNToM]

Jim, 300 is the best dose as far as dopamine is concerned. I believe it inhibits the reuptake of dopamine at this dose by a very tiny amount. Same goes for Zoloft too, at 200mg+ doses.

Don't you already know this Jim?

[jim_morrison]

Originally Posted by RockiNToM

Jim, 300 is the best dose as far as dopamine is concerned. I believe it inhibits the reuptake of dopamine at this dose by a very tiny amount. Same goes for Zoloft too, at 200mg+ doses.

Don't you already know this Jim?

Indeed I do rockintom, but this is the problem that I have with the aforementioned drugs at the high doses you mentioned above, the sheer amount of serotonin your flooding your brain with at these doses is prone to give you alot of serotonin side effects, a balanced reuptake inhibitor would ideally be a better option.

Here are the dosage equivalents btw; 5mg Lexapro = 20mg Celexa = 20mg Paxil = 20mg Prozac = 50mg Zoloft = 75mg Effexor.

So basically 300 mg of effexor is like the equivilent of taking 80 mg of paxil, as far as serotonin side effects are concerned.

Btw, anything that blocks noradrenaline reuptake is going to also boost dopamine neurotransmission in the frontal cortex.

[RockiNToM]

Oh ok I think I see your point. I took 60mg of Paxil in the past by the way, so I don't think it's all that bad.

[Guide 4 Dummies]

I prefer Zoloft + Wellbutrin as far as 'antidepressants' go.

As mentioned before, Zoloft prevents the reuptake of serotonin as well as dopamine (weakly) at 200mg+.

Wellbutrin is a norepinephrine and dopamine reuptake inhibitor, although that's debated.

Originally Posted by Wikipedia

The occupancy of dopamine transporter (DAT) by bupropion and its metabolites in the human brain as measured by positron emission tomography was 6–22% in an independent study[101] and 12–35% according to GlaxoSmithKline researchers.[102] Based on analogy with serotonin reuptake inhibitors, higher than 50% inhibition of DAT would be needed for the dopamine reuptake mechanism to be a major mechanism of the drug's action.

I think if you have the balls to take a relatively high dose (450mg SR) and risk the further decreased seizure threshold, it might be worth it. I'm willing to do this when desperate enough.

[RockiNToM]

It could be done, I mean adding a benzo to help with the possible seizures would be very helpful in making it work.

[Guide 4 Dummies]

Originally Posted by RockiNToM

It could be done, I mean adding a benzo to help with the possible seizures would be very helpful in making it work.

Or any other anticonvulsant for that matter. Not necessarily benzo's.

[RockiNToM]

Yes you could, but you'd have the added benefit of a benzo for anxiety purposes over a standard anticonvulsant which may/not be beneficial, other than keeping seizures at bay.

[Guide 4 Dummies]

Originally Posted by RockiNToM

Yes you could, but you'd have the added benefit of a benzo for anxiety purposes over a standard anticonvulsant which may/not be beneficial, other than keeping seizures at bay.

Correct me if I'm wrong but a standard anticonvulsant would be better on the long run because it will not affect your cognition like long term benzo would (not to mention benzo's long term sexual side effects). You also won't have to deal with tolerance and dependency on standard anticonvulsants, right?

Also, if this regimen works well then there will be no need for a benzo's anxiolytic effects in the first place.

[RockiNToM]

It was just a suggestion, not the be all end all.

[gillettecavalcad3]

All gid again. That was scary to think I'd have to give up my dream combo. I'm
not gonna have a binge like that again.

I can actually feel the Effexor doing it's job again which is a relief.

[jim_morrison]

That's good to hear.