Originally Posted by Recipe For Disaster
are you sure about this? any idea how to do it? i have access to ketamine and am experiencing proctracted benzodiazepine withdrawals. are you telling me that ketamine could help?
Read my thread guys:
Well I am down 50% on my valium now but its not comfortable - I may have to go back up or increase the memantine or add Delsym or something.
I get the distinct impression that DXM is more effective for benzos than memantine is but at the same time, I was taking 60mg of Delsym twice a day versus taking 20mg of memantine twice a day so maybe I just need to go up in the mem dose.
Personally, I think Delsym was working quite well with the valium withdrawal though - my tolerance to it was going down when I was on the Delsym and it started on the second or third day... I switched to memantine due to concerns about drug interactions with DXM but I may switch back because memantine has suppressed my breathing when I take too much (up to 60mg a day) and doesn't appear to be working as well as DXM does. Plus I quit taking drugs altogether in order to do my taper as quickly as possible and get back to work.
Can anyone comment on how well DXM works versus memantine for benzo withdrawal? I would imagine that it is superior - I remember that my valium tolerance dropped on its own when I was doing the Delsym whereas the memantine seems to just reduce the withdrawal symptoms (ie., no brain fog, no memory problems, still functional, no panic attacks, but still psychological symptoms like feeling that your heart is going to give out, weird body feelings, but nothing physical to back it up other than random pains).
It seems to be somewhat commonly reported that for whatever reason, DXM users can keep using the drug they are tolerant to and still experience a tolerance reduction but this does not seem to be the case with memantine.
I guess I may have to just suck it up and switch to the syrup and just make sure to avoid serotonergic drugs, although I wonder how much damage a roll would do with therapeutic levels of Delsym - I won't be trying it though.
I tend to have any adverse reaction that is clinically possible - my body really dislikes pharmaceutical drugs so don't take my word as the final word, it was more a word of caution - but cardiac events do appear to be a problem with memantine.
I switched to DXM starting last night by taking 5mL of Delsym at midnight. I then SKIPPED my Valium dose and took another 5mL at 6AM then fell asleep about 11AM. I woke up about 3PM, which meant I missed my afternoon dose of Valium as well and then about 4:30 I finally took 5mg of Valium and that's all I've had today. I took another 5mL of Delsym when I woke up and another 5mL at 7:30 or so and will take another 5mL at midnight. Normally I'd have taken 20mg of Valium in this time period so there is definitely something to dextromethorphan versus memantine. I should also note that I have experienced no respiratory suppression or heart abnormalities since I stopped taking the memantine, even with the extreme decrease in Valium.
Even more amazing is the fact that when all this went on with the heart racing out of control on the MDMA/Mescaline combo and the drinking that ensued, I ended up taking a full extra 20mg of Valium that day but I'm still able to come down so quickly off of it the day after the fact.
As for the tolerance prevention, just go back on the memantine after you come down from the MDMA. Memantine has quite a long half-life though so there's still a chance that a good bit of it could be in your system even a week later. Even at the low side of 60 hours, that's 2.5 days before your blood level of memantine is halved and another 2.5 days before its quartered, meaning that it takes 5 days to get down to 10mg plasma levels after taking 40mg. On the high end, the half life is 100 hours so you'd be looking at just over 4 days before your plasma levels would hit 20mg after dosing 40mg.
Either way, it seems that all of the NMDA antagonists have the ability to cause severe CNS issues including respiratory failure, heart attack, and stroke, so just be careful with them. Ketamine has been known to cause significant increases in pulse and blood pressure and everyone knows that recreational levels of dextromethorphan cause tachycardia and hypertension.
All that being said, the 120mg of dextromethorphan polisterex I have taken is having less of an impact on my pulse and blood pressure than 40mg of memantine did.
I took Alprazolam for 3 years, then went through accidental cold-turkey withdrawal because the local pharmacies weren't carrying any (happens where I live occasionally, sucky country/city). I experienced severe withdrawal symptoms including paranoia and transient psychosis but soon I got again on Alprazolam and thankfully didn't have a seizure. During that period I was completely tolerant to 2 mg Alprazolam's both sedative and anxiolytic effects.
Since I started taking Memantine, the tolerance was reversed somewhat and 1 mg was anxiolytic and practical enough for social anxiety disorder. 2 mg was very effective sedative. Tolerance didn't develop any further from this point on.
When I began tapering off Alprazolam for good, I was on 2 mg/day and the withdrawal was pretty negligible, only symptoms were irritability and slight sense of panicking, despite the rapid taper process.
I'm totally getting similar results from Huperazine A. I've been taking 100 mcg twice daily for 4 days. I wonder if anyone else can relate to this w/r/t huperazine.
In case it's of interest to you, I've cut my alprazolam consumption in half. Not because I'm trying to give it up but because it's suddenly too potent. FWIW I have a 6-year daily alprazolam habit.
I recommend to read the whole thread for more information and to get an idea on dosing, it seems that DXM is capable of reversing tolerance while memantine rather just slows tolerance, which is probably because DXM hits the same anti addiction receptor as wellbutrin (memantine hits nicotinic receptors too but differend one's.)
A course of DXM certainly wont hurt to try, and then well have some more experiences too.
Regarding the cardiovascular stuff with memantine, it appears to slow down heartrate in some very rare cases, however some caution when combining it with depressants like opiates can be a good idea (get a heartrate monitor or something) and it also appears to potentiate the heartrate increase caused by serotogenic drugs like MDMA in some people.