Social Anxiety Support

Escopeta · 11-02-2009, 02:21 PM

The only thing I understand so far is that irreversible MAOIs shutdown monoamine oxidase for about two weeks, while a reversible is shorter acting, shutting it down for only 48 hours. Is there still a food interaction problem with reversible MAOIs or am I thinking of selective inhibitors?

jim_morrison · 11-02-2009, 06:17 PM

As far as I'm aware the difference is that RIMA's- reversible inhibitors of monoamine oxidase A, are mostly selective to monoamine oxidase type A, and don't have the diet restrictions because eating food with a high tyramine content ie; blue cheese etc causes the tyramine to displace or "reverse" the RIMA drug from the MAOA molecule, so in essence tyramine and RIMAS are competitive.

Vini Vidi Vici · 11-03-2009, 06:59 AM

theres nearly no chance of a hypertensive crisis (only a miniscule one) with Reversible MAOIs. the reversible MAOIs are generally not as powerfull as the irreversible ones, because they don't have much inhibition of MAO-B...thus dopamine levels are not increased as much as with irreversible MAOIs...

11-02-2009, 02:21 PM	#1 (permalink)
Escopeta Status: SAS Member Join Date: Oct 2009 Posts: 11	Difference between an irreversible and reversible MAOI? The only thing I understand so far is that irreversible MAOIs shutdown monoamine oxidase for about two weeks, while a reversible is shorter acting, shutting it down for only 48 hours. Is there still a food interaction problem with reversible MAOIs or am I thinking of selective inhibitors?

11-02-2009, 06:17 PM	#2 (permalink)
jim_morrison Status: SAS Member Join Date: Aug 2008 Location: Australia Gender: Male Age: 23 Posts: 1,027	As far as I'm aware the difference is that RIMA's- reversible inhibitors of monoamine oxidase A, are mostly selective to monoamine oxidase type A, and don't have the diet restrictions because eating food with a high tyramine content ie; blue cheese etc causes the tyramine to displace or "reverse" the RIMA drug from the MAOA molecule, so in essence tyramine and RIMAS are competitive. __________________ Warning: I am not a trained medical professional. Any information provided by me is based on my own personal experiences and research and is not intended to be used as professional medical advice. Please contact a medical professional before taking any action that may be discussed on this board.

11-03-2009, 06:59 AM	#3 (permalink)
Vini Vidi Vici Status: altruistic philanthropist Join Date: Jul 2009 Location: Minnesota Gender: Male Age: 18 Posts: 289	theres nearly no chance of a hypertensive crisis (only a miniscule one) with Reversible MAOIs. the reversible MAOIs are generally not as powerfull as the irreversible ones, because they don't have much inhibition of MAO-B...thus dopamine levels are not increased as much as with irreversible MAOIs... __________________ Please don't take or trust any medical advice from me...Consult a perffessional. meds taken for extended period of time: zyprexa, zoloft, risperdal, klonopin, temazepam, xanax, agomelatine, ambien, adderall, metadate, EMSAM, selegiline, paxil, lexapro, wellbutrin, seroquel, trazodone, clonidine, tramadol, remeron, vyvanse, concerta, Lunesta, Parnate. Current Meds: Parnate 30 mg, Diagnoses- Major Depression, OCD, Social Anxiety, GAD