Are there any other that dont respond to GHB?

[crayzyMed]

GHB doesnt even touch my anxiety, as it seems like a miracle treatment for a alot ppl i tought it may be usefull to discuss with ppl that are like me so i could find a good treatment.
The only thing that works perfect for my anxiety is MDMA. The after antianxiety effects seem to last all into the next day.

[UltraShy]

I wouldn't know as I've never used either. I failed to try them back in the day when they were legal. Of course, in the case of MDMA that means I'd have needed to try it by age 11, since it was banned as a C-I drug in 1984.

[crayzyMed]

Recreational substances are imo a great way to find out what neurotransmitters could be involved.
Opiates, GHB, Benzo's, alcohol all dont work for my social anxiety. Only high dose amphetamine (low dose intesifies it) and MDMA seem to work. I'm thinking its my serotonin system.

[euphoria]

Originally Posted by crayzyMed

GHB doesnt even touch my anxiety, as it seems like a miracle treatment for a alot ppl i tought it may be usefull to discuss with ppl that are like me so i could find a good treatment!!!!

GHB (well, GBL mostly) initially killed my SA and the reason for it (anhedonia, unsociability, depression, etc.), but over time that faded. It also made me too cognitively messed up to be functional, although I would've denied that at the time. I don't think it's the miracle cure people say it is.

The only thing that works perfect for my anxiety is MDMA!!!!! The effects last all next day!! I just feel a nice afterglow, sober and no anxiety!!

You don't take it regularly I assume? MDMA can cause permanent damage to your serotonin nerve cells, which in the long run could make SA a lot worse.

[crayzyMed]

Originally Posted by euphoria

GHB (well, GBL mostly) initially killed my SA and the reason for it (anhedonia, unsociability, depression, etc.), but over time that faded. It also made me too cognitively messed up to be functional, although I would've denied that at the time. I don't think it's the miracle cure people say it is.



You don't take it regularly I assume? MDMA can cause permanent damage to your serotonin nerve cells, which in the long run could make SA a lot worse.

Hmm i've never noticed a tolerance to GBL, but i allways limited my doses tough and kept the doses as low as possible.

[nork123]

I've only recently heard about this GBL stuff and im gunna take the opportunity to buy a big 5 or 10 leter bottle of it while I still can because it is going to be made illegal here in the UK by the end of the year so I figured I might as well give it a try before that happens. What's the deal with it though, because i've heard it described as a "party drug" so is it intoxicating? or does it just reduce anxiety and act like a social lubricant?

[crayzyMed]

Originally Posted by nork123

I've only recently heard about this GBL stuff and im gunna take the opportunity to buy a big 5 or 10 leter bottle of it while I still can because it is going to be made illegal here in the UK by the end of the year so I figured I might as well give it a try. What's the deal with it though, because i've heard it described as a "party drug" so is it intoxicating? or does it just reduce anxiety and act like a social lubricant?

It produces euphoria and is used as a party drug, i used it daily for months to induce euphoria, i only used max 2 doses a day tough. It didnt make me social as my SA didnt respond to it, but it is considered a social drug tough, so for most ppl it definatly make you social.

You cant take this stuff 24/7 or you will get addicted.

[Ash09]

GBL is great, I'm also planning to buy in bulk before the ban comes into effect and turn it into GHB. Moderate doses of GBL makes me throw up if I don't use metoclopramide though.

[belfort]

GHb is the only thing out there that gives me the DESIRE to socialize..alcohol used to do that but on a lesser scale..GHB worked wonders for me, just wish i could find some...never developed a tolerance for it and i used to buy it by the gallon...

[crayzyMed]

Originally Posted by belfort

GHb is the only thing out there that gives me the DESIRE to socialize..alcohol used to do that but on a lesser scale..GHB worked wonders for me, just wish i could find some...never developed a tolerance for it and i used to buy it by the gallon...

Yeah i never noticed a tolerance either. How much did you use it?

[belfort]

^^i would use it at most 3 times a week, sometimes dosing a few times a day...no tolerance buildup, a capful and a half worked like a charm when i started and when i stopped using..

benzos by themself are just garbage for me...

[crayzyMed]

Originally Posted by belfort

^^i would use it at most 3 times a week, sometimes dosing a few times a day...no tolerance buildup, a capful and a half worked like a charm when i started and when i stopped using..

benzos by themself are just garbage for me...

Yeah benzo's are complete crap, GHB doesnt affect my SA either but its GREAT for anhedonia. And yeah you really need to use ALOT to get tolerance for this.

[belfort]

yep, GHb worked great for my anhedonia as well..GHb worked on several different fronts for me...bottom line, GHb made me feel how i am supposed to feel, minus the euphoria...

how does alcohol work for you crazymed??

[crayzyMed]

Originally Posted by belfort

yep, GHb worked great for my anhedonia as well..GHb worked on several different fronts for me...bottom line, GHb made me feel how i am supposed to feel, minus the euphoria...

how does alcohol work for you crazymed??

Alcohol sucks...
When i try in low doses at home it makes me tired so i dont enjoy it, and the euphoria is crap, when i drink alot at a party you kinda feel like crap and good at the same time.. Terrible toxic drug.

Nothing like the energizing euphoria from GHB.

[belfort]

yep, GHb gave me tons of energy...it also had a strange effect of making me FEEL leaner..not sure what that was due to but it worked...

[nork123]

Originally Posted by crayzyMed

Alcohol sucks...
When i try in low doses at home it makes me tired so i dont enjoy it, and the euphoria is crap, when i drink alot at a party you kinda feel like crap and good at the same time.. Terrible toxic drug.

Nothing like the energizing euphoria from GHB.

I find I get different effects from different kinds of alcohol, like if I drink loads of beer it usually makes me feel quite monged out and crappy, but if I drink a spirit or liquer or something I get more of a happy buzz. Either way I hardly drink anymore because I can't stand the hang overs, so im looking to GHB as a possible alcohol replacement as well as for reducing social anxiety

[crayzyMed]

Originally Posted by belfort

yep, GHb gave me tons of energy...it also had a strange effect of making me FEEL leaner..not sure what that was due to but it worked...

Well, they have given GBL to rats and they actually lived longer and got leaner.

[Freesix88]

bodybuilders use ghb for recovery so it can't be so bad.

[crayzyMed]

Originally Posted by Freesix88

bodybuilders use ghb for recovery so it can't be so bad.

Its been shown to be completely safe when studied before XYREM has been aproved, so its been established that its safe for humans.

http://www.ncbi.nlm.nih.gov/pubmed/1...m&ordinalpos=3
Theres no abstract on this one, if anyone could get the paper?

Sodium oxybate: efficacy, safety and tolerability in the treatment of narcolepsy with or without cataplexy.
Owen RT.

Medical Information Department, Prous Science, Barcelona, Spain. journals@prous.com
Sodium oxybate is the sodium salt of gamma- hydroxybutyrate, an endogenous cerebral inhibitory neurotransmitter. It is licensed in the United States for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy and in the European Union for the treatment of narcolepsy with cataplexy. Its mode of action is uncertain, but it increases 5-hydroxytryptamine turnover, interacts with opioid systems and may act as a gamma-aminobutyric acid B receptor agonist (GABA(B)). It is rapidly absorbed and eliminated, having a mean elimination half-life of 30-60 minutes. In controlled trials in narcolepsy without cataplexy, it decreased excessive daytime sleepiness and increased several quality of life domains. In combination with modafinil, it exerted an additive effect in diminishing daytime sleepiness. Both acute (four to eight weeks) and chronic (12 months) studies have demonstrated sodium oxybate's efficacy in decreasing cataplectic attack frequency. It is well tolerated with adverse event withdrawal rates of approximately 3-10% after acute and chronic administration. There is no clear evidence of a withdrawal syndrome after abrupt cessation of therapeutic doses. Sodium oxybate appears to be an effective and well-tolerated treatment for all the key symptoms of the two forms of narcolepsy.

Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers.
Carter LP, Griffiths RR, Mintzer MZ.

Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W. Markham Street #843, Little Rock, AR 72205, USA.
RATIONALE: Illicit gamma-hydroxybutyrate (GHB) has received attention as a "date rape drug" that produces robust amnesia; however, there is little experimental evidence in support of GHB's amnestic effects. OBJECTIVES: This study compared the cognitive effects of GHB (sodium oxybate) with those of triazolam in healthy volunteers. MATERIALS AND METHODS: Doses of sodium oxybate (1.125, 2.25, and 4.5 g/70 kg), triazolam (0.125, 0.25, and 0.5 mg/70 kg), and placebo were administered to 15 volunteers under repeated measures, counterbalanced, double-blind, double-dummy conditions. The time course and peak physiological, psychomotor, subjective, and cognitive effects were examined. RESULTS: Sodium oxybate and triazolam produced similar increases in participant ratings of drug effects. Performance on psychomotor, working memory, and episodic memory tasks was impaired to a greater extent after triazolam than sodium oxybate. CONCLUSIONS: Together, these data suggest that sodium oxybate produces less psychomotor and cognitive impairment than triazolam at doses that produce equivalent participant-rated subjective effects in healthy volunteers.

[belfort]

^^actually, i dont believe GHB to be that helpful to bodybuilders as G raises cortisol levels...not a good thing if ya want bigger muscles...

GHB was also by far the best aphrodisiac out there...

i also cant remember ever taking GHb and being in a bad mood...whereas with alcohol, it is very hit and miss, sometimes it makes me happy and sometimes it makes me sleepy and dull..GHb always gave me energy and optimism...

i really cant think of any negative sides with GHb besides the nasty taste(just mix it with OJ) and the potential for addiction which i have only seen 1-2 people become addicted to it...and trust me, i have known hundreds of people that have taken it over the years...