I think it's been a long enough time to have waited to 'bump' this thread, because I would really like to have some sort of answer to my previous post by anyone well-versed in pharmacology. Again, I asked my psychiatrist and he said that "there shouldn't be anything to worry about"
Basically how long should I wait after stopping a tramadol 100mg dose to take my Adderall XR 10 mg dose. Should I wait hours? Should I stop tramadol completely and wait several days? I would have to take Adderall XR in the morning and if it is okay to take both medications at the same time, would I only wait several hours to take the tramadol again? What should be an appropriate length of time to wait to avoid any of the possible serotonin releasing/norepinephrine reuptake inhibition interaction?
When I check on the Medscape interaction database, this is what I get:
1. Dextro and tramadol both increase serotonin levels. Potential for interaction, monitor.
2. Tramadol decreases and Dextro increases sedation. (I'm not worried about this since I am also taking Clonazepam. I have taken Clonazepam with adderall xr together and experience no problems.)
3. Dextro increases effects of tramadol by unspecified interaction mechanism. Minor or non-significant interaction
Drugs.com gives the following interaction...
1. MONITOR CLOSELY: The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, and theophylline. These agents are often individually epileptogenic and may have additive effects when combined. Many of these agents also exhibit CNS- and/or respiratory-depressant effects, which may be enhanced during their concomitant use with tramadol.
MANAGEMENT: Caution is advised if tramadol is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with epilepsy, a history of seizures, or other risk factors for seizures (e.g., head trauma, brain tumor, metabolic disorders, alcohol and drug withdrawal, CNS infections).
Since I am also on Clonzepam 3mg daily, wouldn't this not be a problem?
Other websites list no interactions between tramadol and adderall xr.
Since Tramadol inhibits the reuptake of norepinephrine like an antidepressant, wouldn't it take days of tapering down the dose, for it to reach a normal level again and avoid any complications?
Again, all of these questions henge on the assumption that it is not okay
to take both tramadol and adderall xr together. Which could be totally incorrect. If it is okay
, could anyone explain if it is?
I've been searching and searching just to be on the safe side and my health care provider gave me an "It's okay" answer, however, it wasn't thorough enough to explain why it was okay to puts my thoughts at ease.
Thanks for the help.