Not sure what vini is talking about....lot of dude and man in there lol, although definitely on track about the MAOIs.Anyway, not all psychotropic drugs are the same. I find that SSRIs did nothing for me except one in particular that took me past baseline. It was a great time before it pooped out.
SSRIs tend to make you feel sleepy, spaced out, and all that junk, while not really doing anything in the mean time. Conversely, the older drugs shouldn't be shot down either, and I think they deserve to be on the same plane as the SSRIs. The side effects are the main reason why many people down play these drugs, but you, or I, or any other who's suffered from depression, or anxiety will take the side effects if it gives us the relief we want.
I think therapy is a great option and CBT has been shown to rewire the frontal cortex. Older drugs like the TCAs and MAOIs can be MORE effective in some people for depression, it just all depends on the type. The way I see it, when you try SSRIs, and you get that boost in serotonin they say, what does that matter when your real problem is an abundance of MAO that breaks down the serotonin anyway, and gives you no real relief. Research, therapy, knowledge, and the right drug/combination will go a far way.