Social Anxiety Support

crayzyMed · 11-04-2009, 10:34 AM

I think whey is waaaay to weak to work for OCD...

soto · 11-04-2009, 07:35 PM

hey odspot, sounds like you've already tried alot of options so are getting an idea of what works and doesn't - i have done alot of research on inositol, there are over a hundred papers on it if you include the animal research - no one knows exactly how it works yet but it works on the phosphatidylinositol secondary messenger system that is linked to G-protein coupled receptors, the most notable of these being 5-HT2 receptors that are implicated in all anxiety and mood disorders. It definitely does something in the way of modifying serotonin transporter function or receptor sensitivity or some such. Animal research has isolated it's effects to the 5-HT2 receptor, but no more specific than that.

jez- whey protein may be an option, products like immunocal that have high quantities of protein-bound cysteine could theoretically do the same thing as NAC, but there aren't any clinical trials that have been done to investigate it yet - I suspect that NAC is a better cysteine donor - it is not glutathione which is responsible for normalizing glutamate but the cysteine (according to the pittenger paper). But maybe worth a shot.

As for myself I am still on 1200mg/day NAC and finding that it is doing a great job - but I am little less motivated and sharp at work, so I don't think I'll be upping the dose further any time soon. I am taking the second dose around 1 or 2 pm in the afternoon instead of evening because I think it makes me a bit restless at night to sleep - however I could be wrong.

I have also stopped taking the inositol in conjunction with the NAC today as I suspect there is an interaction, I have scoured the net but not found any other reports of this. The kind of effect I was getting with high dose inositol together with NAC was reflux and slight shortness of breath, which has dissapeared when I've cut out the Inositol. I have no idea what kind of chemical reaction would cause this, but my body is better on NAC by itself.
Maybe it's just me.

odspot · 11-04-2009, 09:16 PM

hey thanks for your help soto. it is hard to distinguish between Parnate withdrawal and NAC's effects, but i am almost 100% convinced that it is having some benefit. i feel a little slower as well, but again, their are numerous complicating factors. i also read, from a very reliable source on another forum, that a "flu" reaction to NAC is almost undoubtedly a sign of chlamydia pneumoniae (http://www.cpnhelp.org/). take that as you will (whoever experienced the reaction), but i know i had a Herx-like response to NAC w/ flu symptoms, diarrhea (sorry

), etc. so i don't think i'll stop taking at least 600mg for a while.

strange you experienced reflux soto. i hate to sound like a complete mimic, but my reflux has been worse lately as well for some reason - i've always suffered from it (it waxes and wanes based on my anxiety levels) but for the first time lately i've been experiencing severe burning in my throat at night. i wonder if it is linked to NAC. i can't comment on the insomnia, because i sleep badly in general.

anyway, interesting to know about the inositol-NAC interaction in you. i may start off with just SAMe and NAC, and see how i fare; SAM-e made me a little hyper, so maybe NAC could regulate that this time.

soto · 11-05-2009, 11:40 PM

hey odspot - yeah i read the stuff about chlamydia and NAC flu as well, haha i got tested for this stuff a few months ago

so my reaction is prob something else - but if I did have chlamydia it's good to know it's now being killed off

.

I'm really not the best person to judge side effects, because I have OCD and lie awake thinking "is my heart beat different today?" - you know how it is always imaging worse case scenario. The PAH stuff has made me do google searches galore looking for NAC effects on blood pressure - I can't really find any bad effects other than that 1 paper, so I have more-or-less accepted the risk.

I don't want to give up on the inositol - it has been a very positive experience, so I will try starting it again at a lower dose after a few days break - try it for yourself cause my experience could be nothing to do with it.

11-04-2009, 10:34 AM	#41 (permalink)
crayzyMed Status: Crazy Member!! Join Date: Nov 2006 Location: Belguim Gender: Male Age: 21 Posts: 390	I think whey is waaaay to weak to work for OCD...

11-04-2009, 07:35 PM	#42 (permalink)
soto Status: SAS Member Join Date: Oct 2009 Posts: 9	hey odspot, sounds like you've already tried alot of options so are getting an idea of what works and doesn't - i have done alot of research on inositol, there are over a hundred papers on it if you include the animal research - no one knows exactly how it works yet but it works on the phosphatidylinositol secondary messenger system that is linked to G-protein coupled receptors, the most notable of these being 5-HT2 receptors that are implicated in all anxiety and mood disorders. It definitely does something in the way of modifying serotonin transporter function or receptor sensitivity or some such. Animal research has isolated it's effects to the 5-HT2 receptor, but no more specific than that. jez- whey protein may be an option, products like immunocal that have high quantities of protein-bound cysteine could theoretically do the same thing as NAC, but there aren't any clinical trials that have been done to investigate it yet - I suspect that NAC is a better cysteine donor - it is not glutathione which is responsible for normalizing glutamate but the cysteine (according to the pittenger paper). But maybe worth a shot. As for myself I am still on 1200mg/day NAC and finding that it is doing a great job - but I am little less motivated and sharp at work, so I don't think I'll be upping the dose further any time soon. I am taking the second dose around 1 or 2 pm in the afternoon instead of evening because I think it makes me a bit restless at night to sleep - however I could be wrong. I have also stopped taking the inositol in conjunction with the NAC today as I suspect there is an interaction, I have scoured the net but not found any other reports of this. The kind of effect I was getting with high dose inositol together with NAC was reflux and slight shortness of breath, which has dissapeared when I've cut out the Inositol. I have no idea what kind of chemical reaction would cause this, but my body is better on NAC by itself. Maybe it's just me.

11-04-2009, 09:16 PM	#43 (permalink)
odspot Status: SAS Member Join Date: Aug 2009 Posts: 15	hey thanks for your help soto. it is hard to distinguish between Parnate withdrawal and NAC's effects, but i am almost 100% convinced that it is having some benefit. i feel a little slower as well, but again, their are numerous complicating factors. i also read, from a very reliable source on another forum, that a "flu" reaction to NAC is almost undoubtedly a sign of chlamydia pneumoniae (http://www.cpnhelp.org/). take that as you will (whoever experienced the reaction), but i know i had a Herx-like response to NAC w/ flu symptoms, diarrhea (sorry ), etc. so i don't think i'll stop taking at least 600mg for a while. strange you experienced reflux soto. i hate to sound like a complete mimic, but my reflux has been worse lately as well for some reason - i've always suffered from it (it waxes and wanes based on my anxiety levels) but for the first time lately i've been experiencing severe burning in my throat at night. i wonder if it is linked to NAC. i can't comment on the insomnia, because i sleep badly in general. anyway, interesting to know about the inositol-NAC interaction in you. i may start off with just SAMe and NAC, and see how i fare; SAM-e made me a little hyper, so maybe NAC could regulate that this time.

11-05-2009, 11:40 PM	#44 (permalink)
soto Status: SAS Member Join Date: Oct 2009 Posts: 9	hey odspot - yeah i read the stuff about chlamydia and NAC flu as well, haha i got tested for this stuff a few months ago so my reaction is prob something else - but if I did have chlamydia it's good to know it's now being killed off . I'm really not the best person to judge side effects, because I have OCD and lie awake thinking "is my heart beat different today?" - you know how it is always imaging worse case scenario. The PAH stuff has made me do google searches galore looking for NAC effects on blood pressure - I can't really find any bad effects other than that 1 paper, so I have more-or-less accepted the risk. I don't want to give up on the inositol - it has been a very positive experience, so I will try starting it again at a lower dose after a few days break - try it for yourself cause my experience could be nothing to do with it.