GABA is made from L-glutamine in the body. This reaction is dependent of LYsine. The more Lysine, the more GABA is produced..naturally. This means you don't have to worry about it crossing the BBB or anything like that. Lysine is cheap and worth the try
I gave Lysine to my brother because I read that it helps regrow hair. I started him on a conservative supplement regime for anxiety, insomnia, stress and overall health. He's been taking fish oil, magnesium, taurine and some other stuff and he says he's been feeling great... Anyways, I decided to look into Lysine a little closer and this is what i found:
There's a relationship between diets low in Lysine and stress levels.
-Lysine controls herpes virus and outbreaks.
-Lysine is a precursor to carnitine (think L-carnitine!!) This can help burn fat and increase memory and concentration.
-can boost human growth hormone.
-can reduce Lipoprotein (a) and protect from heart disease.
-Good immune booster
Biomed Res. 2007 Apr;28(2):85-90.
Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans.Smriga M, Ando T, Akutsu M, Furukawa Y, Miwa K, Morinaga Y.
Institute of Life Sciences, Ajimoto Co. Inc, 1-1 Suzuki-cho, 210-8681 Kawasaki-ku, Kawasaki-shi, Japan. firstname.lastname@example.org
Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.
PMID: 17510493 [PubMed - indexed for MEDLINE]
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8285-8.
Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria.
Smriga M, Ghosh S, Mouneimne Y, Pellett PL, Scrimshaw NS.
Institute of Life Sciences, Ajinomoto Co., Inc., 210-8681 Kawasaki, Japan.
Lysine is a limiting amino acid in diets based on wheat as the staple. In experimental animals, prolonged dietary lysine inadequacy increases stress-induced anxiety. If observed in humans, such a result would have a strong implication for the relationship between nutrition and communal quality of life and mental health. As part of a 3-month randomized double-blind study, we tested whether lysine fortification of wheat reduces anxiety and stress response in family members in poor Syrian communities consuming wheat as a staple food. In the lysine-fortified group, the plasma cortisol response to the blood drawing as a cause of stress was reduced in females, as was sympathetic arousal in males as measured by skin conductance. Lysine fortification also significantly reduced chronic anxiety as measured by the trait anxiety inventory in males. These results suggest that some stress responses in economically weak populations consuming cereal-based diets can be improved with lysine fortification.
PMID: 15159538 [PubMed - in process]
GABA, the (benzo-like) inhibitory neurotransmitter requires adequate Lysine in order for its conversion from GABA's precursor - Glutamate - to take place.
from here http://www.mindandmuscle.net/forum/inde ... sine&st=30
Someone claims they reduces their use of benzos by 90% after using lysine. How many here take Benzo?
This makes me wonder. What is happening to our food? We seem to be deficient in everything. We're not getting enough magnesium, taurine, thiamin...Lysine? The list goes on....