Ill have to agree with ultrashy on that one. I wouldn't say completely useless because everybody reacts differently. I took paxil for a while which i would say did nothing for my anxiety, and helped somewhat for depression. Celexa made me very depressed but did an ok job for my anxiety. lexapro i only took for about 3 weeks so i dont know if it really did anything or not. now that i am off all medication, i exercise daily. my sa is overall a bit worse then when i wasn't on meds and same with depression, but my body feels so much better, thats for sure. My panic attacks have been reduced greatly as well. the only combo i felt had ever worked was when i took klonopin and any antidepressants together, i felt very happy. I still am prescribed klonopin and have probably used 10 pills in the last year, because it has not worked for me by itself. thats my story on meds.