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Originally Posted by Erowid
SSRIs tend to cause reduced physiological and mental effects when taken before MDMA. A study for which there was a poster at the College on Problems of Drug Dependence in June of 2002, administered 20mg Paroxetine (Paxil, a common dosage) orally to subjects for 3 days before administering MDMA. Subjects had reduced experiential and physiological responses to the MDMA.
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http://www.erowid.org/chemicals/mdma/mdma_info9.shtml
Effexor is an SNRI, but the above holds true for any serotonin reuptake inhibiting drug.