Yea, that is what I was thinking too. I tried lexapro a long time ago, and it worked almost immediately, but then I started itching, so my doctor took me off of it. I may see if I can try it again. I know it is supposed to be really good for anxiety. I guess anything, including my situation with xanax xr, is a trade-off. It gets rid of the anxiety, but you just have to deal with the fatigue/flatness. Bleh..... Sorry the cymbalta didn't work for you. I have a doctor's appt. early December, so I guess I could either stick with the pristiq until then, or just go back on my xanax er and see how I do, and then discuss the lexapro with him, if I still feel depressed. Which do you think I should do?