Its likely always going to make you tired.
Frankly I wasn't able to grasp the scope of or even recognize my major depression until I got on a med which treated it and then it was a light bulb moment of "oh, because normal people feel like this is why everyone else isn't choking back tears every minute of the day like me". Point: take the new class of med and see if it helps, simple.
Pristiq makes me nervous just like effexor. Every SSRI/SNRI is different and will have different effects on every individual.